Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
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Published:2018-07-09
Issue:8
Volume:24
Page:1192-1203
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ISSN:1078-8956
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Container-title:Nature Medicine
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language:en
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Short-container-title:Nat Med
Author:
Bunse LukasORCID, Pusch StefanORCID, Bunse Theresa, Sahm Felix, Sanghvi Khwab, Friedrich Mirco, Alansary Dalia, Sonner Jana K., Green Edward, Deumelandt Katrin, Kilian Michael, Neftel Cyril, Uhlig Stefanie, Kessler Tobias, von Landenberg Anna, Berghoff Anna S., Marsh Kelly, Steadman Mya, Zhu Dongwei, Nicolay Brandon, Wiestler Benedikt, Breckwoldt Michael O., Al-Ali Ruslan, Karcher-Bausch Simone, Bozza Matthias, Oezen Iris, Kramer Magdalena, Meyer Jochen, Habel Antje, Eisel Jessica, Poschet Gernot, Weller Michael, Preusser Matthias, Nadji-Ohl Minou, Thon Niklas, Burger Michael C., Harter Patrick N., Ratliff Miriam, Harbottle Richard, Benner Axel, Schrimpf Daniel, Okun Jürgen, Herold-Mende Christel, Turcan Sevin, Kaulfuss Stefan, Hess‐Stumpp Holger, Bieback Karen, Cahill Daniel P., Plate Karl H., Hänggi Daniel, Dorsch Marion, Suvà Mario L.ORCID, Niemeyer Barbara A., von Deimling Andreas, Wick WolfgangORCID, Platten Michael
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference71 articles.
1. Yang, M., Soga, T. & Pollard, P. J. Oncometabolites: Linking altered metabolism with cancer. J. Clin. Invest. 123, 3652–3658 (2013). 2. Erez, A. & DeBerardinis, R. J. Metabolic dysregulation in monogenic disorders and cancer—finding method in madness. Nat. Rev. Cancer 15, 440–448 (2015). 3. Pollard, P. J. et al. Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations. Hum. Mol. Genet. 14, 2231–2239 (2005). 4. Ward, P. S. et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 17, 225–234 (2010). 5. Dang, L. et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462, 739–744 (2009).
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