Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"-Reference-Cited by-同舟云学术

Comment on "A Common Genetic Variant Is Associated with Adult and Childhood Obesity"

Published:2007-01-12 Issue:5809 Volume:315 Page:187-187
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Dina Christian¹²³⁴⁵,Meyre David¹²³⁴⁵,Samson Chantal¹²³⁴⁵,Tichet Jean¹²³⁴⁵,Marre Michel¹²³⁴⁵,Jouret Beatrice¹²³⁴⁵,Charles Marie Aline¹²³⁴⁵,Balkau Beverley¹²³⁴⁵,Froguel Philippe¹²³⁴⁵

Affiliation:

1. CNRS 8090-Institute of Biology, Pasteur Institute, Lille, France.

2. Institut Inter-Régional pour la Santé, Tours, France.

3. Department of Diabetology, Bichat Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, France.

4. Institut National de la Santé et de la Recherche Médicale (INSERM) U563, Children's Hospital, Toulouse, France.

5. INSERM U780-IFR69, Villejuif, France.

Abstract

Herbert et al . (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference11 articles.

1. A Common Genetic Variant Is Associated with Adult and Childhood Obesity

2. J. Ott, Neurology63, 955 (2004).

3. N. Bouatia-Naji et al., Diabetes55, 545 (2006).

4. C. G. Bell et al., Diabetes53, 1857 (2004).

5. J. Hager et al., Nat. Genet.20, 304 (1998).

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