A Common Genetic Variant Is Associated with Adult and Childhood Obesity-Reference-Cited by-同舟云学术

A Common Genetic Variant Is Associated with Adult and Childhood Obesity

Published:2006-04-14 Issue:5771 Volume:312 Page:279-283
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Herbert Alan¹²³⁴⁵,Gerry Norman P.¹²³⁴⁵,McQueen Matthew B.¹²³⁴⁵,Heid Iris M.¹²³⁴⁵,Pfeufer Arne¹²³⁴⁵,Illig Thomas¹²³⁴⁵,Wichmann H.-Erich¹²³⁴⁵,Meitinger Thomas¹²³⁴⁵,Hunter David¹²³⁴⁵,Hu Frank B.¹²³⁴⁵,Colditz Graham¹²³⁴⁵,Hinney Anke¹²³⁴⁵,Hebebrand Johannes¹²³⁴⁵,Koberwitz Kerstin¹²³⁴⁵,Zhu Xiaofeng¹²³⁴⁵,Cooper Richard¹²³⁴⁵,Ardlie Kristin¹²³⁴⁵,Lyon Helen¹²³⁴⁵,Hirschhorn Joel N.¹²³⁴⁵,Laird Nan M.¹²³⁴⁵,Lenburg Marc E.¹²³⁴⁵,Lange Christoph¹²³⁴⁵,Christman Michael F.¹²³⁴⁵

Affiliation:

1. Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA.

2. Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.

3. Institute of Epidemiology, Forschungszentrum fuÌr Umwelt und Gesundheit, D-85764 Neuherberg, Germany.

4. KORA Group, Forschungszentrum fuÌr Umwelt und Gesundheit, D-85764 Neuherberg, Germany.

5. Institute of Human Genetics, Forschungszentrum fuÌr Umwelt und Gesundheit, D-85764 Neuherberg, Germany.

Abstract

Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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