Developmental cell programs are co-opted in inflammatory skin disease-Reference-Cited by-同舟云学术

Developmental cell programs are co-opted in inflammatory skin disease

Published:2021-01-22 Issue:6527 Volume:371 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Reynolds Gary¹^ORCID,Vegh Peter¹^ORCID,Fletcher James¹^ORCID,Poyner Elizabeth F. M.¹²^ORCID,Stephenson Emily¹^ORCID,Goh Issac¹^ORCID,Botting Rachel A.¹^ORCID,Huang Ni³^ORCID,Olabi Bayanne¹⁴^ORCID,Dubois Anna¹²^ORCID,Dixon David¹^ORCID,Green Kile¹^ORCID,Maunder Daniel¹,Engelbert Justin¹,Efremova Mirjana³,Polański Krzysztof³^ORCID,Jardine Laura¹,Jones Claire¹^ORCID,Ness Thomas¹^ORCID,Horsfall Dave¹^ORCID,McGrath Jim¹^ORCID,Carey Christopher¹^ORCID,Popescu Dorin-Mirel¹,Webb Simone¹^ORCID,Wang Xiao-nong¹^ORCID,Sayer Ben¹^ORCID,Park Jong-Eun³^ORCID,Negri Victor A.⁵^ORCID,Belokhvostova Daria⁵^ORCID,Lynch Magnus D.⁵,McDonald David¹^ORCID,Filby Andrew¹^ORCID,Hagai Tzachi⁶^ORCID,Meyer Kerstin B.³^ORCID,Husain Akhtar⁷^ORCID,Coxhead Jonathan¹,Vento-Tormo Roser³^ORCID,Behjati Sam³⁸^ORCID,Lisgo Steven¹^ORCID,Villani Alexandra-Chloé⁹¹⁰^ORCID,Bacardit Jaume¹¹^ORCID,Jones Philip H.³¹²^ORCID,O’Toole Edel A.¹³,Ogg Graham S.¹⁴^ORCID,Rajan Neil¹²^ORCID,Reynolds Nick J.²¹⁵^ORCID,Teichmann Sarah A.³¹⁶^ORCID,Watt Fiona M.⁵^ORCID,Haniffa Muzlifah¹²³^ORCID

Affiliation:

1. Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

2. Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK.

3. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

4. Department of Dermatology, NHS Lothian, Lauriston Building, Edinburgh EH3 9EN, UK.

5. Centre for Stem Cells and Regenerative Medicine, King’s College London, Guy’s Hospital Campus, London SE1 9RT, UK.

6. Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

7. Department of Pathology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.

8. Department of Paediatrics, University of Cambridge, Cambridge CB2 0SP, UK.

9. Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

10. Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA.

11. School of Computing, Newcastle University, Newcastle upon Tyne NE4 5TG, UK.

12. MRC Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK.

13. Centre for Cell Biology and Cutaneous Research, Blizard Institute, Queen Mary University of London, London, UK.

14. MRC Human Immunology Unit, Oxford Biomedical Research Centre, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

15. Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

16. Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK.

Abstract

Cellular beauty is skin deep Human skin works as barrier, preventing the entry of pathogens, among other functions. Reynolds et al. used single-cell sequencing to generate an atlas of the human skin from both developing and adult sources, identifying differences and similarities across heterogeneous populations of skin cells. In this atlas, gene expression in the two disease states studied—atopic dermatitis and psoriasis—varied from that in a healthy adult, suggesting that a fetal skin signature is expressed in adult inflamed skin. Furthermore, differences in immune cell composition between healthy fetal and adult skin and that of individuals suffering from disease were observed. Science , this issue p. eaba6500

Funder

Wellcome

Medical Research Council

Lister Institute of Preventive Medicine

NIHR Newcastle Biomedical Research Centre

Medical Research Council UK, NIHR Oxford Biomedical Research Centre and NIHR Clinical Research Network

NIHR Biomedical Research Centre, Guy’s and St Thomas’ NHS Foundation Trust

Chan Zuckerberg Initiative

Cancer Research UK

Publisher

American Association for the Advancement of Science (AAAS)

Subject