Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer-Reference-Cited by-同舟云学术

Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer

Published:2017-12-15 Issue:6369 Volume:358 Page:1443-1448
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Bullman Susan¹²^ORCID,Pedamallu Chandra S.¹²,Sicinska Ewa¹,Clancy Thomas E.³,Zhang Xiaoyang¹²,Cai Diana¹²,Neuberg Donna¹^ORCID,Huang Katherine²,Guevara Fatima¹,Nelson Timothy¹^ORCID,Chipashvili Otari¹^ORCID,Hagan Timothy¹^ORCID,Walker Mark²^ORCID,Ramachandran Aruna¹²,Diosdado Begoña¹²^ORCID,Serna Garazi⁴^ORCID,Mulet Nuria⁴,Landolfi Stefania⁴^ORCID,Ramon y Cajal Santiago⁴,Fasani Roberta⁴,Aguirre Andrew J.¹²³,Ng Kimmie¹,Élez Elena⁴,Ogino Shuji¹³⁵^ORCID,Tabernero Josep⁴^ORCID,Fuchs Charles S.⁶,Hahn William C.¹²³^ORCID,Nuciforo Paolo⁴^ORCID,Meyerson Matthew¹²³^ORCID

Affiliation:

1. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

2. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

3. Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

4. Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology, Barcelona, CIBERONC, Universitat Autònoma de Barcelona, Spain.

5. Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

6. Yale Cancer Center, Yale School of Medicine, New Haven, CT 06520, USA.

Abstract

Bacteria go the distance in cancer The bacterial species Fusobacterium nucleatum is associated with a subset of human colorectal cancers, but its role in tumorigenesis is unclear. Studying patient samples, Bullman et al. found that F. nucleatum and certain co-occurring bacteria were present not only in primary tumors but also in distant metastases. Preliminary evidence suggests that the bacterium is localized primarily within the metastatic cancer cells rather than in the stroma. Antibiotic treatment of mice carrying xenografts of F. nucleatum –positive human colorectal cancer slowed tumor growth, consistent with a causal role for the bacterium in tumorigenesis. Science , this issue p. 1443

Funder

National Institutes of Health

Prevent Cancer Foundation

National Institute of Health

DF/HCC GI SPORE P50

American Cancer Society Research Professorship

Cellex Private Foundation

Banco Bilbao Vizcaya Argentaria Foundation

Hale Family Center for Pancreatic Cancer

Project P Fund for Colorectal Cancer Research

Stand-up-to-Cancer

Chambers Family Fund for Colorectal Cancer Research