Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota-Reference-Cited by-全球学者库

Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota

Published:2012-10-05 Issue:6103 Volume:338 Page:120-123
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Arthur Janelle C.¹,Perez-Chanona Ernesto¹,Mühlbauer Marcus¹,Tomkovich Sarah¹,Uronis Joshua M.¹,Fan Ting-Jia¹,Campbell Barry J.²,Abujamel Turki³⁴,Dogan Belgin⁵,Rogers Arlin B.⁶,Rhodes Jonathan M.²,Stintzi Alain³,Simpson Kenneth W.⁵,Hansen Jonathan J.¹,Keku Temitope O.¹,Fodor Anthony A.⁷,Jobin Christian¹

Affiliation:

1. Department of Medicine, Pharmacology and Immunology-Microbiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

2. Department of Gastroenterology, University of Liverpool, Liverpool L69 3BX, UK.

3. Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ontario K1H 8M5, Canada.

4. Department of Medical Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

5. Department of Clinical Sciences, Cornell University, Ithaca, NY 14853, USA.

6. Lineberger Comprehensive Cancer Center, Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

7. Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.

Abstract

Of Microbes and Cancer Inflammation is a well-established driver of tumorigenesis. For example, patients with inflammatory bowel disease have an elevated risk of developing colorectal cancer (CRC). Whether the gut microbiota also contributes to the development of CRC is less well understood. Arthur et al. (p. 120 , published online 16 August; see the Perspective by

Schwabe and Wang

) now show that the microbiota does indeed promote tumorigenesis in an inflammation-driven model of CRC in mice. Although germ-free mice were protected against developing cancer, colonization of mice with Escherichia coli was sufficient to drive tumorigenesis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. Inflammation and cancer: back to Virchow?

2. Intestinal Inflammation and Cancer

3. A cytokine-mediated link between innate immunity, inflammation, and cancer

4. Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin–Yang interplay between inflammation and cancer

5. Modulation of the Intestinal Microbiota Alters Colitis-Associated Colorectal Cancer Susceptibility

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