Resetting histone modifications during human parental-to-zygotic transition-Reference-Cited by-全球学者库

Resetting histone modifications during human parental-to-zygotic transition

Published:2019-07-26 Issue:6451 Volume:365 Page:353-360
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Xia Weikun¹^ORCID,Xu Jiawei²^ORCID,Yu Guang¹^ORCID,Yao Guidong²^ORCID,Xu Kai¹,Ma Xueshan²^ORCID,Zhang Nan²^ORCID,Liu Bofeng¹,Li Tong²,Lin Zili¹,Chen Xia³,Li Lijia¹,Wang Qiujun¹,Shi Dayuan²,Shi Senlin²^ORCID,Zhang Yile²,Song Wenyan²^ORCID,Jin Haixia²^ORCID,Hu Linli²,Bu Zhiqin²,Wang Yang²,Na Jie³^ORCID,Xie Wei¹^ORCID,Sun Ying-Pu²^ORCID

Affiliation:

1. Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, THU-PKU Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

2. Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.

3. Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University, Beijing 100084, China.

Abstract

Epigenetics of human embryonic development Substantial epigenetic reprogramming occurs in mammalian early development. Xia et al. investigated the reprogramming dynamics of three key histone modifications in human early embryonic development. The reprogramming in humans is highly species-specific and different than that in mice. A globally permissive chromatin state connects parental and zygotic epigenomes during maternal-to-zygotic transition. Inner-cell mass-specific, but not trophectoderm-specific, genes are asymmetrically patterned by a histone mark during early lineage segregation. Science , this issue p. 353

Funder

National Natural Science Foundation of China

National Basic Research Program of China

National Key R&D Program

HHMI International Research Scholar

THU-PKU Center for Life Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference64 articles.

1. Signals and Combinatorial Functions of Histone Modifications