Polycomb silencing mechanisms and the management of genomic programmes
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg1981.pdf
Reference148 articles.
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2. Jurgens, G. A group of genes controlling the spatial expression of the bithorax complex in Drosophila. Nature 316, 153–155 (1985).
3. Poux, S., Horard, B., Sigrist, C. J. & Pirrotta, V. The Drosophila Trithorax protein is a coactivator required to prevent re-establishment of Polycomb silencing. Development 129, 2483–2493 (2002).
4. Klymenko, T. & Muller, J. The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins. EMBO Rep. 5, 373–377 (2004). References 3 and 4 provide evidence that the main role of TRX in the regulation of Hox genes is to prevent PcG silencing, rather than simply to activate their transcription.
5. Buchenau, P., Hodgson, J., Strutt, H. & Arndt-Jovin, D. J. The distribution of polycomb-group proteins during cell division and development in Drosophila embryos: impact on models for silencing. J. Cell Biol. 141, 469–481 (1998).
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