Prognostic Value of the Preoperative Ratio of Fibrinogen to Prealbumin in Patients Undergoing Radical Resection for Lung Cancer

Abstract

Abstract Background and Objective It has been proven that The ratio of fibrinogen to prealbumin (FPR) has a significant effect on the prognosis of gastric cancer, colorectal cancer, esophageal cancer and other malignant tumors, but there are few studies on its effect on the prognosis of patients with resectable non-small cell lung cancer. This study aims to analyze the relationship between FPR and the postoperative clinicopathologic features and prognosis of non-small cell lung cancer. Methods The clinical follow-up pathological data of 289 patients who underwent radical resection of lung cancer and were confirmed as NSCLC by postoperative pathology were analyzed retrospectively, and the FPR values were calculated according to the serological test results within 1 week before surgery. The critical value of FPR (cut-off value) was obtained by analyzing the receiver operating characteristic curve (ROC). Kaplan-Meier survival curve and Cox proportional risk model were used to study the effect of FPR on the prognosis of patients with non-small cell lung cancer after surgery. Results 5-year survival was used as the end point to draw the ROC curve of the FPR value. When the FPR value was 10.96, the Youden index was the largest, the sensitivity was 62.4%, and the specificity was 69.6%. The cumulative five-year survival rate of the low FPR group was significantly higher than that of the high FPR group. Univariate and multivariate analysis showed that age, TNM stage and FPR level were significantly correlated with survival rate (P < 0.05). Conclusion As a new inflammatory marker, the FPR level can effectively predict the prognosis of patients with non-small cell lung cancer after radical resection.