Therapeutic Enzymes Used for the Treatment of Non-Deficiency Diseases

Abstract

Therapeutic enzymes have a broad variety of specific uses and clinical applications, particularly as antineoplasic agents, wound debridement therapeutics, and anti-inflammatory drugs, etc. These enzymes can elicit immune response, contributing allergic reactions. Newer drugs with improved stability and less antigenicity have been developed. Covalent modification of enzymes is used to circumvent this immunogenicity. Advancements in drug delivery have revolutionized enzyme therapy. Microencapsulation and artificial liposomal entrapment are some of the techniques used to increment the stability and half-life of enzyme drugs. Several enzymes are now used as prodrug that metabolizes inactive substances into active metabolites through bioactivation process. This approach comprises a suit of techniques that allow activation of drugs locally and at the site of action. This chapter gives an outline of clinical uses of therapeutic enzymes used in non-deficiency diseases. Developments of these enzymes are reviewed with a particular focus on bioengineering applied to the native proteins.