High-density mapping of primate digit representations with a 1152-channel µECoG array

Author:

Kaiju TaroORCID,Inoue Masato,Hirata Masayuki,Suzuki Takafumi

Abstract

Abstract Objective. Advances in brain–machine interfaces (BMIs) are expected to support patients with movement disorders. Electrocorticogram (ECoG) measures electrophysiological activities over a large area using a low-invasive flexible sheet placed on the cortex. ECoG has been considered as a feasible signal source of the clinical BMI device. To capture neural activities more precisely, the feasibility of higher-density arrays has been investigated. However, currently, the number of electrodes is limited to approximately 300 due to wiring difficulties, device size, and system costs. Approach. We developed a high-density recording system with a large coverage (14 × 7 mm2) and using 1152 electrodes by directly integrating dedicated flexible arrays with the neural-recording application-specific integrated circuits and their interposers. Main results. Comparative experiments with a 128-channel array demonstrated that the proposed device could delineate the entire digit representation of a nonhuman primate. Subsampling analysis revealed that higher-amplitude signals can be measured using higher-density arrays. Significance. We expect that the proposed system that simultaneously establishes large-scale sampling, high temporal-precision of electrophysiology, and high spatial resolution comparable to optical imaging will be suitable for next-generation brain-sensing technology.

Funder

National Institute of Information and Communications Technology

Japan Society for the Promotion of Science

Core Research for Evolutional Science and Technology

Publisher

IOP Publishing

Subject

Cellular and Molecular Neuroscience,Biomedical Engineering

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