Chromanones from Lentinus crinitus (Basidiomycetes)

Abstract

The fungus Lentinus crinitus DR-5 (Basidiomycotina) produces in submerse culture the new natural products 2,2-dimethyl-6-methoxy-4-chromanone 1, its alcohol 3 and (S)-2,2-di-methyl-3-hydroxy-6-methoxy-4-chromanone 2. Beside these merohemiterpenes the antibioti-cally active hirsutane sesquiterpenes 5 -8 were isolated. The formation of these metabolites displayed strong dependence from the carbon source in the medium. While lactose favoured the formation of the antibiotic sesquiterpene ketones 5 and 6, they were suppressed with mannose where the hemiterpenes 1 and 4 and the hirsutane-diol 8 were the dominating metabolites.