Schwann cells in neuromuscular in vitro models

Author:

Hörner Sarah Janice123ORCID,Couturier Nathalie123,Hafner Mathias14,Rudolf Rüdiger1235

Affiliation:

1. Institute of Molecular and Cell Biology, Mannheim University of Applied Sciences , D-68163 Mannheim , Germany

2. Interdisciplinary Center for Neurosciences , Heidelberg University , D-69117 Heidelberg , Germany

3. Center for Mass Spectrometry and Optical Spectroscopy , Mannheim University of Applied Sciences , D-68163 Mannheim , Germany

4. Institute of Medical Technology, Heidelberg University and Mannheim University of Applied Sciences , D-69117 Heidelberg , Germany

5. Mannheim Center for Translational Neuroscience , Medical Faculty Mannheim Heidelberg University , D-68167 Mannheim , Germany

Abstract

Abstract Neuromuscular cell culture models are used to investigate synapse formation and function, as well as mechanisms of de-and regeneration in neuromuscular diseases. Recent developments including 3D culture technique and hiPSC technology have propelled their ability to complement insights from in vivo models. However, most cultures have not considered Schwann cells, the glial part of NMJs. In the following, a brief overview of different types of neuromuscular cocultures is provided alongside examples for studies that included Schwann cells. From these, findings concerning the effects of Schwann cells on those cultures are summarized and future lines of research are proposed.

Funder

Bundesministerium für Bildung und Forschung

Deutsche Forschungsgemeinschaft

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

Reference30 articles.

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