Immunoglobulin G Enhances Generation of Inducible T Regulatory Cells and Increases Their Regulatory Function

Author:

Okuda Sachio1,Kamei Shintaro1,Sasaki Takumi1

Affiliation:

1. Therapeutic Protein Products Research Department, The Chemo-Sero-Therapeutic Research Institute (Kaketsuken) (currently KM Biologics Co., Ltd.)

Publisher

Pharmaceutical Society of Japan

Subject

Pharmaceutical Science,Pharmacology,General Medicine

Reference33 articles.

1. 1) Perez EE, Orange JS, Bonilla F, Chinen J, Chinn IK, Dorsey M, El-Gamal Y, Harville TO, Hossny E, Mazer B, Nelson R, Secord E, Jordan SC, Stiehm ER, Vo AA, Ballow M. Update on the use of immunoglobulin in human disease: A review of evidence. J. Allergy Clin. Immunol., 139 (3S), S1–S46 (2017).

2. 2) Heyman B. Regulation of Antibody Responses via Antibodies, Complement, and Fc Receptors. Annu. Rev. Immunol., 18, 709–737 (2000).

3. 3) Schwab I, Nimmerjahn F. Intravenous immunoglobulin therapy: How does IgG modulate the immune system? Nat. Rev. Immunol., 13, 176–189 (2013).

4. 4) Kaufman GN, Massoud AH, Dembele M, Yona M, Piccirillo CA, Mazer BD. Induction of Regulatory T Cells by Intravenous Immunoglobulin: A Bridge between Adaptive and Innate Immunity. Front. Immunol., 6, 469 (2015).

5. 5) Ohkura N, Kitagawa Y, Sakaguchi S. Development and Maintenance of Regulatory T cells. Immunity, 38, 414–423 (2013).

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