Neuroprotective effect of canagliflozin against cisplatin-induced cerebral cortex injury is mediated by regulation of HO-1/PPAR-γ, SIRT1/FOXO-3, JNK/AP-1, TLR4/iNOS, and Ang II/Ang 1

Neuroprotective effect of canagliflozin against cisplatin-induced cerebral cortex injury is mediated by regulation of HO-1/PPAR-γ, SIRT1/FOXO-3, JNK/AP-1, TLR4/iNOS, and Ang II/Ang 1–7 signals

Published:2022-11-11 Issue: Volume: Page:1-13
ISSN:0892-3973
Container-title:Immunopharmacology and Immunotoxicology
language:en
Short-container-title:Immunopharmacology and Immunotoxicology

Author:

Hassanein Emad H. M.¹,Saleh Fayez M.²,Ali Fares E. M.¹^ORCID,Rashwan Eman K.³,Atwa Ahmed M.⁴,Abd El-Ghafar Omnia A. M.⁵

Affiliation:

1. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

2. Department of Medical Microbiology, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia

3. Department of Physiology, College of Medicine, Al-Azhar University, Assiut, Egypt

4. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt

5. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt

Publisher

Informa UK Limited

Subject

Pharmacology,Toxicology,General Medicine,Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.1080/08923973.2022.2143371

Reference71 articles.

1. Platinum neurotoxicity pharmacogenetics

2. Chemotherapy-induced peripheral neuropathy: Prevention and treatment strategies

Neuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation

4. Melatonin rescues the mice brain against cisplatin-induced neurodegeneration, an insight into antioxidant and anti-inflammatory effects

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