The enteroprotective effect of nifuroxazide against methotrexate-induced intestinal injury involves co-activation of PPAR-γ, SIRT1, Nrf2, and suppression of NF-κB and JAK1/STAT3 signals

Author:

Abd-alhameed Esraa K.,Azouz Amany A.ORCID,Abo-Youssef Amira M.,Ali Fares E.M.ORCID

Publisher

Elsevier BV

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference47 articles.

1. Methotrexate–how does it really work?;Chan;Nat. Rev. Rheumatol.,2010

2. Overview of methotrexate toxicity: a comprehensive literature review;Hamed;Cureus,2022

3. Taurine attenuated methotrexate-induced intestinal injury by regulating NF-κB/iNOS and Keap1/Nrf2/HO-1 signals;Hassanein;Life Sci.,2022

4. Berberine and/or zinc protect against methotrexate-induced intestinal damage: role of GSK-3β/NRF2 and JAK1/STAT-3 signaling pathways;Hassanein;Life Sci.,2021

5. Nrf2 signaling pathway: pivotal roles in inflammation;Ahmed;Biochim. Biophys. Acta Mol. Basis Dis.,2017

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