Selective intrarenal delivery of mesenchymal stem cell-derived extracellular vesicles attenuates myocardial injury in experimental metabolic renovascular disease

Author:

Zhang Lei,Zhu Xiang-Yang,Zhao Yu,Eirin Alfonso,Liu Lei,Ferguson Christopher M.,Tang Hui,Lerman Amir,Lerman Lilach O.ORCID

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

National Heart, Lung, and Blood Institute

Publisher

Springer Science and Business Media LLC

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Reference57 articles.

1. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr, International Diabetes Federation Task Force on E, Prevention, National Heart L, Blood I, American Heart A, World Heart F, International Atherosclerosis S, International Association for the Study of O (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120:1640–1645. https://doi.org/10.1161/CIRCULATIONAHA.109.192644

2. Bagno L, Hatzistergos KE, Balkan W, Hare JM (2018) Mesenchymal stem cell-based therapy for cardiovascular disease: progress and challenges. Mol Ther 26:1610–1623. https://doi.org/10.1016/j.ymthe.2018.05.009

3. Baranyai T, Herczeg K, Onodi Z, Voszka I, Modos K, Marton N, Nagy G, Mager I, Wood MJ, El Andaloussi S, Palinkas Z, Kumar V, Nagy P, Kittel A, Buzas EI, Ferdinandy P, Giricz Z (2015) Isolation of exosomes from blood plasma: qualitative and quantitative comparison of ultracentrifugation and size exclusion chromatography methods. PLoS ONE 10:e0145686. https://doi.org/10.1371/journal.pone.0145686

4. Chrysochou C, Kalra PA (2009) Epidemiology and natural history of atherosclerotic renovascular disease. Prog Cardiovasc Dis 52:184–195. https://doi.org/10.1016/j.pcad.2009.09.001

5. Davidson SM, Andreadou I, Barile L, Birnbaum Y, Cabrera-Fuentes HA, Cohen MV, Downey JM, Girao H, Pagliaro P, Penna C, Pernow J, Preissner KT, Ferdinandy P (2019) Circulating blood cells and extracellular vesicles in acute cardioprotection. Cardiovasc Res 115:1156–1166. https://doi.org/10.1093/cvr/cvy314

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