Obesity blunts amelioration of cardiac hypertrophy and fibrosis by human mesenchymal stem/stromal cell-derived extracellular vesicles-Reference-Cited by-同舟云学术

Obesity blunts amelioration of cardiac hypertrophy and fibrosis by human mesenchymal stem/stromal cell-derived extracellular vesicles

Published:2023-07-01 Issue:1 Volume:325 Page:H163-H171
ISSN:0363-6135
Container-title:American Journal of Physiology-Heart and Circulatory Physiology
language:en
Short-container-title:American Journal of Physiology-Heart and Circulatory Physiology

Author:

Hong Siting¹²,Huang Weijun¹³,Zhu Xiangyang¹,Tang Hui¹,Krier James D.¹,Xing Li¹,Lu Bo¹,Gandhi Deep¹^ORCID,Jordan Kyra L.¹,Saadiq Ishran M.¹,Lerman Amir⁴,Eirin Alfonso¹^ORCID,Lerman Lilach O.¹^ORCID

Affiliation:

1. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, United States

2. Department of Cardiology, First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China

3. Key Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, People’s Republic of China

4. Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States

Abstract

Injection of A-MSC-derived EVs harvested from patients who are lean can resolve myocardial injury in mice with experimental renovascular hypertension more effectively than A-MSC-derived EVs from patients with obesity. These observations underscore and might have important ramifications for the self-healing capacity of patients with obesity and for the use of autologous EVs as a regenerative tool.

Funder

China Scholarship Council

National Natural Science Foundation of China

HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases

HHS | NIH | National Heart, Lung, and Blood Institute

HHS | NIH | National Institute on Aging

Publisher

American Physiological Society

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Link

https://journals.physiology.org/doi/pdf/10.1152/ajpheart.00676.2022

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