Phase 1 study of N 1,N 11-diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma

Author:

Goyal Lipika,Supko Jeffrey G.,Berlin Jordan,Blaszkowsky Lawrence S.,Carpenter Amanda,Heuman Douglas M.,Hilderbrand Sarah L.,Stuart Keith E.,Cotler Scott,Senzer Neil N.,Chan Emily,Berg Carl L.,Clark Jeffrey W.,Hezel Aram F.,Ryan David P.,Zhu Andrew X.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference33 articles.

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2. Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF et al (2008) Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 359(4):378–390

3. Porter CW, Bergeron RJ (1988) Regulation of polyamine biosynthetic activity by spermidine and spermine analogs: a novel antiproliferative strategy. Adv Exp Med Biol 250:677–690

4. Porter CW, Pegg AE, Ganis B, Madhabala R, Bergeron RJ (1990) Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N 1 N 12 -bis(ethyl)spermine. Biochem J 268(1):207–212

5. Porter CW, Ganis B, Libby PR, Bergeron RJ (1991) Correlations between polyamine analogue-induced increases in spermidine/spermine N 1 -acetyltransferase activity, polyamine pool depletion, and growth inhibition in human melanoma cell lines. Cancer Res 51(14):3715–3720

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