Asparaginase Erwinia chrysanthemi effectively depletes plasma glutamine in adult patients with relapsed/refractory acute myeloid leukemia

Author:

Emadi AshkanORCID,Law Jennie Y.,Strovel Erin T.,Lapidus Rena G.,Jeng Linda J. B.,Lee Myounghee,Blitzer Miriam G.,Carter-Cooper Brandon A.,Sewell Danielle,Van Der Merwe Isabella,Philip Sunita,Imran Mohammad,Yu Stephen L.,Li Hongxia,Amrein Philip C.,Duong Vu H.,Sausville Edward A.,Baer Maria R.,Fathi Amir T.,Singh Zeba,Bentzen Søren M.

Funder

Jazz Pharmaceuticals

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology

Reference18 articles.

1. Buchner T, Schlenk RF, Schaich M, Dohner K, Krahl R, Krauter J, Heil G, Krug U, Sauerland MC, Heinecke A, Spath D, Kramer M, Scholl S, Berdel WE, Hiddemann W, Hoelzer D, Hehlmann R, Hasford J, Hoffmann VS, Dohner H, Ehninger G, Ganser A, Niederwieser DW, Pfirrmann M (2012) Acute myeloid leukemia (AML): different treatment strategies versus a common standard arm—combined prospective analysis by the German AML intergroup. J Clin Oncol 30(29):3604–3610. doi: 10.1200/JCO.2012.42.2907

2. Estey E, Levine RL, Lowenberg B (2015) Current challenges in clinical development of “targeted therapies”: the case of acute myeloid leukemia. Blood 125(16):2461–2466. doi: 10.1182/blood-2015-01-561373

3. Willems L, Jacque N, Jacquel A, Neveux N, Maciel TT, Lambert M, Schmitt A, Poulain L, Green AS, Uzunov M, Kosmider O, Radford-Weiss I, Moura IC, Auberger P, Ifrah N, Bardet V, Chapuis N, Lacombe C, Mayeux P, Tamburini J, Bouscary D (2013) Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia. Blood 122(20):3521–3532. doi: 10.1182/blood-2013-03-493163

4. Jacque N, Ronchetti AM, Larrue C, Meunier G, Birsen R, Willems L, Saland E, Decroocq J, Maciel TT, Lambert M, Poulain L, Hospital MA, Sujobert P, Joseph L, Chapuis N, Lacombe C, Moura IC, Demo S, Sarry JE, Recher C, Mayeux P, Tamburini J, Bouscary D (2015) Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition. Blood 126(11):1346–1356. doi: 10.1182/blood-2015-01-621870

5. Emadi A, Zokaee H, Sausville EA (2014) Asparaginase in the treatment of non-ALL hematologic malignancies. Cancer Chemother Pharmacol 73(5):875–883. doi: 10.1007/s00280-014-2402-3

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3