Asparaginase Erwinia chrysanthemi effectively depletes plasma glutamine in adult patients with relapsed/refractory acute myeloid leukemia
Author:
Funder
Jazz Pharmaceuticals
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Cancer Research,Pharmacology,Toxicology,Oncology
Link
http://link.springer.com/article/10.1007/s00280-017-3459-6/fulltext.html
Reference18 articles.
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2. Estey E, Levine RL, Lowenberg B (2015) Current challenges in clinical development of “targeted therapies”: the case of acute myeloid leukemia. Blood 125(16):2461–2466. doi: 10.1182/blood-2015-01-561373
3. Willems L, Jacque N, Jacquel A, Neveux N, Maciel TT, Lambert M, Schmitt A, Poulain L, Green AS, Uzunov M, Kosmider O, Radford-Weiss I, Moura IC, Auberger P, Ifrah N, Bardet V, Chapuis N, Lacombe C, Mayeux P, Tamburini J, Bouscary D (2013) Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia. Blood 122(20):3521–3532. doi: 10.1182/blood-2013-03-493163
4. Jacque N, Ronchetti AM, Larrue C, Meunier G, Birsen R, Willems L, Saland E, Decroocq J, Maciel TT, Lambert M, Poulain L, Hospital MA, Sujobert P, Joseph L, Chapuis N, Lacombe C, Moura IC, Demo S, Sarry JE, Recher C, Mayeux P, Tamburini J, Bouscary D (2015) Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition. Blood 126(11):1346–1356. doi: 10.1182/blood-2015-01-621870
5. Emadi A, Zokaee H, Sausville EA (2014) Asparaginase in the treatment of non-ALL hematologic malignancies. Cancer Chemother Pharmacol 73(5):875–883. doi: 10.1007/s00280-014-2402-3
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