教育经历学士,第三军医大学,临床医学专业,1984~1989年硕士,同济医科大学,病理生理专业,1991~1994年博士,第一军医大学,病理生理专业,1995~1998年 办公电话: 0755-86671912Email: ljljz@yahoo.com, lvmoyang@126.com 主要工作经历1989年-1991年,第三军医大学病理生理学教研室, 助教1995年-2003年,第一军医大学病理生理学教研室, 讲师 2001年-2003年,美国VCU大学,生理系,博士后2003年-2008年,南方医科大学病理生理学教研室, 副教授、教授2005年-2006年,北京大学分子医学研究所,兼职副教授2009年至今,深圳大学,医学部医学院院医学系,教授 研究方向1. 正常与疾病心脏离子通道和钙信号的调节机制2. 心肌肥大、心衰的发病机制和治疗科研项目(包括主持和参与的)主持项目1. 国家自然科学基金:KCNE2调节心肌细胞L-型钙通道的分子机制及其生理和病理意义(31171096),2012年1月-2015年12月。2. 国家自然科学基金:FKBP12.6对RyR2功能调控异常在烧伤心脏肌浆网钙漏流增加发生机制中的作用(30973122),2010年1月-2012年12月。3. 深圳市基础研究重点项目:心脏成纤维细胞在心衰心脏离子通道重构中的作用及治疗策略(JC201005250059A),2010年1月-2013年12月。4. 深圳市基础研究重点项目:MiRP1 在房颤发生中的作用及作为房颤治疗新靶点的研究(JCYJ20120613115535998),2013年1月-2014年12月 代表性成果论文(*表示通讯作者)1. Jiang X, Liu W, Deng J, Lan L, Xue X, Zhang C, Cai G, Luo X, Liu J*. Polydatin protects cardiac function against burn injury by inhibiting sarcoplasmic reticulum Ca2+ leak by reducing oxidative modification of ryanodine receptors. Free Radic Biol 2013; 60: 292-9. 2. Deng JX, Liu WJ, Wang YR, Dong M, Zheng M, Liu J*. Polydatin modulates Ca2+ handling, excitation-contraction coupling and b-adrenergic signaling in rat ventricular myocytes. J Mol Cell Cardiol, 2012; 53(5): 646-656.3. Yang C, Mo X, Lv J, Liu X, Yuan M, Dong M, Li L, Luo X, Fan X, Jin Z, Liu Z, Liu J*. Lipopolysaccharide enhances FcRI-mediated mast cell degranulation by increasing Ca2+ entry through store-operated Ca2+ channels: implications for LPS exacerbating allergic asthma. Exp Physiol, 2012; 97: 1315 - 1327.4. Yuan M, Li J, Lv J, Mo X, Yang C, Chen X, Liu Z, Liu J* Polydatin (PD) inhibits IgE-mediated passive cutaneous anaphylaxis in mice by stabilizing mast cells through modulating Ca(2+) mobilization. Toxicol Appl Pharmacol, 2012; 264:462-469.5. Luo X, Deng J, Liu N, Zhang C, Huang Q, Liu J*. Cellular mechanism underlying burn serum-generated bidirectional regulation of excitation-contraction coupling in isolated rat cardiomyocytes. Shock, 2011; 35(4): 388-95.6. Liu W, Deng J, Xu J, Wang H, Yuan M, Liu N, Jiang Y, Liu J*. High-mobility group box 1 (HMGB1) downregulates cardiac transient outward potassium current (Ito) through downregulation of Kv4.2 and Kv4.3 channel transcripts and proteins. J Mol Cell Cardiol, Sep 2010; 49(3): 438-48.7. Wang G, Zhu X, Xie W, Han P, Li K, Sun Z, Wang Y, Chen C, Song R, Cao C, Zhang J, Wu C, Liu J*, Cheng H. Rad As a Novel Regulator of Excitation–Contraction Coupling and -Adrenergic Signaling in Heart. Circ Res 2010; 306:317-327.8. Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, L i K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JPY, Lakatta1 EG., Sheu S-S, Ouyang K, Chen J, Dirksen RT, Cheng H. Superoxide Flashes in Single Mitochondria. Cell 2008 25;134(2):279-90.9. Yan Y, Liu J*, Wei C, Li K, Xie W, Wang Y, Cheng H*. Bidirectional Regulation of Ca2+ Sparks by Mitochondria-Derived ROS in Cardiac Myocytes. Cardiovasc Res, 2008; 77(2): 432-441.10. Deng J, Wang G, Huang Q, Yan Y, Li, Tan W, Jin C, Wang Y, Liu J*. Oxidative Stress Induced Leaky Sarcoplasmic Reticulum Underlying Acute Heart Failure in Severe Burn Trauma. Free Radical Biology & Medicine. 2008; 44(3): 375-385.11. Liu W, Wang H, Chen W, Deng J, Jiang Y, Liu J*. Co-expression of KCNE2 and KChIP2c modulates the electrophysiological properties of Kv4.2 current in COS-7 cells. Acta Pharmacologica Sinica 2008; 29(6):653-660.12. Zhao G, Zhao Y, Pan B, Liu J, Huang X, Zhang X, Cao C, Hou N, Wu C, Zhao K, Cheng H. Hypersensitivity of BKCa to Ca2+ Sparks Underlies Hyporeactivity of Arterial Smooth Muscle in Shock. Circ Res. 2007;101:493-502.13. Yan Y, Wei C, Zhang W, Cheng H, Liu J*. Cross-talk between calcium and reactive oxygen species signaling. Acta Pharmacologica Sinica. 2006; 27 (7): 821–826.14. Zhang M, Liu J, Jiang M, Wu DM, Sonawane K, Guy HR, Tseng GN. Interactions between charged residues in the transmembrane segments of the voltage-sensing domain in the hERG channel. J Membr Biol, 2005; 207(3): 169-81.15. Zhang M, Liu J, Tseng GN. Gating Charges in the Activation and Inactivation Processes of the hERG Channel. J Gen Physiol 2004; 124: 703 - 718.16. Jiang M, Zhang M, Tang D, Clemo H, Liu J, Holwitt D, Kasirajan V, Pond AL, Wettwer E, Tseng GN. KCNE2 protein is expressed in ventricles of different species, and changes in its expression contribnute to electrical remodeling in diseased hearts. Circ 2004; 109: 1783-1788.17. Liu J, Zhang M, Jiang M, Tseng G-N. Negative charges in the transmembrane domains of the HERG K channel are involved in the activation and deactivation gating processes. J Gen Physiol 2003;121: 599-614.18. Liu J, Zhang M, Jiang M, Tseng G-N. Structural and functional role of the extracellular S5-P linker in the HERG potassium channel. J Gen Physiol 2002; 120: 723-737.获奖情况1. 赵克森、刘杰、黄绪亮、黄巧冰、姜勇、金春华、阚文宏、赵桂林、潘秉兴。重症休克的发病机理。广东省科技进步一等奖,2011。2. 赵克森、刘杰、黄绪亮、金春华、赵桂林、阚文宏、潘秉兴、黄巧冰。血管平滑肌钾通道激活和细胞膜超极化参与休克低血管反应性发生,军队科技进步二等奖,2005。