个人学习工作简介 2002-2006年 西北农林科技大学 本科 2006-2009年 西北农林科技大学 硕士 2010-2013年 西北农林科技大学 博士 2013年9月-至今 合肥工业大学,生物医学工程系 讲师 获奖情况 2011年度教育部“博士研究生学术新人奖”; 2012年杨凌示范区科学技术一等奖(厅级)(排名第二); 2012陕西省科学技术奖二等奖(省级)(排名第三)。 著作论文(代表作) 近年来先后在《Nucleic Acid Research》、《RNA》、《Current Medicinal Chemistry》、《Soft Matter》和《PloS one》等刊物上发表SCI论文30余篇。 1. Xu X*, Wang X*, Li Y, Wang Y, Yang L. A large-scale association study for nanoparticle C60 uncovers mechanisms of nanotoxicity disrupting the native conformations of DNA/RNA. Nucleic Acids Res. 2012, 40:7622-7632. (*equal contribution to first author) 2. Wang X, Xu X, Ma Z, Huo Y, Xiao Z, Li Y, Wang Y. Dynamic mechanisms for pre-miRNA binding and export by Exportin-5. RNA. 2011. 17:1511-1528. 3. Wang X, Li Y, Xu X, Wang Y. Toward a system-level understanding of microRNA pathway via mathematical modeling. Biosystems, 2010;100: 31-38. 4. Tao W, Xu X, Wang X, Yu H, Li X, Li B, Wang Y. Yang L. Network target-based uncovering the mechanism of action of Chinese herbal Radix Curcumae formula with application to cardiovascular disease. Journal of Ethnopharmacology. 5. Zhou W, Li Y, Wang X, Wu L, Wang Y. MiR-206-mediated dynamic mechanism of the mammalian circadian clock. BMC Syst Biol. 2011, 5:141-157. 6. Wang X, Xu X, Li Y, Li X, Tao W, Li B, Wang Y, Yang L. Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication. Integr Biol (Camb). 2013, 28;5(2):351-71. 7. Wang X, Xu X, Tao W, Li Y, Wang Y, Yang L. A systems biology approach to uncovering pharmacological synergy in herbal medicines with applications to cardiovascular disease. Evid Based Complement Alternat Med. 2012:519031 doi: 10.1155/2012/519031. 8. Wang X, Xu X, Ma M, Zhou W, Wang Y, Yang L. pH-dependent channel gating in connexin26 hemichannels involves conformational changes in N-terminus. Biochim Biophys Acta Biomembr.2012;1818:1148-1157. 9. Wang X, Xu X, Zhu S, Xiao Z, Ma Z, Li Y, Wang Y. Molecular dynamics simulation of conformational heterogeneity in Transportin 1. Proteins. 2012; 80:382?397. 10. Xu X*, Wang X*, Xiao Z, Li Y, Wang Y. Two TPX2-Dependent Switches Control the Activity ofAurora A. PLoS ONE, 2011; 6(2): e16757. (*equal contribution to first author) 11. Xu X*, Wang X*, Xiao Z, Li Y, Wang Y. Probing the structural and functional link between mutation- and pH-dependent hydration dynamics and amyloidosis of transthyretin. Soft matter.2012; 8:324-336. (*equal contribution to first author) 12. Xu X, Li R, Ma M, Wang X, Wang Y, Zou H. Multidrug resistance protein P-glycoprotein does not recognize nanoparticle C60: experiment and modeling. Soft Matter, 2012, 8: 2915-2923. 13. Xiao Z, Wang X, Xu X, Zhang H, Li Y, Wang Y. Base- and Structure-Dependent DNA Dinucleotide-Carbon Nanotube Interactions: Molecular Dynamics Simulations and Thermodynamic Analysis. J. Phys. Chem. C, 2011, 115(44): 21546-21558. (cover paper) 14. Wang X, Yang W, Xu X, Zhang H, Li Y, Wang Y. Studies of benzothiadiazine derivatives as hepatitis C virus NS5B polymerase inhibitors using 3D-QSAR, molecular docking and molecular dynamics. Curr Med Chem. 2010;17:2788-2803.