黄河清,男,湖北十堰人,生于1965年1月,医学博士,教 授/主任医师,博士生导师;中山大学药学院中药复方与活性物质研究所所长,兼任中山大学实验动物中心副主任、动物实验部(北校区)主任。主要学术团体任职为:中国药理学会中药药理专业委员会常务委员,广东省中西医结合学会理事,广东省药理学会理事,广东省药理学会中药药理专业委员会副主任委员。 研究方向主要为心血管及内分泌疾病的中药药理与中西医结合防治研究。近几年来负责国家自然科学基金、粤港关健领域重点突破招标项目、广东省重大新药创制专项项目、广东省自然科学基金、广东省科技计划重点与面上项目、广州市科技计划重大专项项目等纵向研究课题10余项,承担多项重大横向合作研究课题;累积在国内外期刊发表学术论文近百篇,其中近几年来在糖尿病(肾病)、血管硬化性疾病研究中发表与本项目相关研究论文38篇(SCI收录期刊论文20余篇,通讯作者18篇);研制的具有独立自主知识产权、治疗2型糖尿病合并高脂血症的疗效独特的中药新药——糖脉交泰胶囊获得国家食品药品监督管理局临床试验批文,已进入3期临床试验-;目前在研和即将启动2个具有独立自主知识产权、治疗高血压合并胰岛素抵抗等代谢综合症的中药新药临床前研究。获得中国发明专利授权3项,获得5项省部科研成果奖励。 办公电话:020-39943028,020-87331190电子邮箱:huangheq@mail.sysu.edu.cn 主要学习与工作经历 1991年7月 毕业于湖北中医学院硕士研究生。1991年8月-1995年8月 在湖北省十堰市人民医院(三甲医院)从事中西医结合内科临床工作。1995年9月-1998年8月 在成都中医药大学攻读中医内科(血管疾病方向)博士学位,其间在四川省人民医院内科临床工作一年。1998年9月-2000年7月 在原中山医科大学(现中山大学中山医学院)从事动脉粥样硬化病理生理学(中西医结合)博士后研究工作。2000年8月-2002年9月 在广东省中医研究所、广东省第二中医院从事中西医结合防治糖尿病、心脑血管病临床工作。2002年10月至今 在中山大学药学院、中山大学实验动物中心等单位从事药理学、中西医结合教、研、医工作。 近年来负责的主要纵向研究项目如下:1、2012、1—2015、12:Sphk-1/S1p信号通路调节糖尿病肾脏纤维化的作用与机制,国家自然科学基金,编号:81170676,经费:50万元。2、2011、10—2014、10:糖脉交泰胶囊治疗2型糖尿病合并高脂血症的Ⅲ期临床研究,广东省重大新药创制专项项目,编号:2011A080502004,经费:150万元。3、2010、7—2012、7:糖脉交泰治疗2型糖尿病合并高血症的临床研究,广州市科技计划项目:编号:10A32060084,经费:30万元。4、2009、1--2012、1:大黄素调节p38MAPK信号通路抗糖尿病肾病的研究,国家自然科学基金,编号:30873427,经费:30万元。5、2009、1--2012、1:糖脉交泰治疗糖尿病合并高血脂等慢性血管并发症的新药研发,粤港关健领域重点突破招标项目,编号:2008A03060008,经费:100万元。6、2004、10--至2007、12:血脉舒抗糖尿病肾病五类(原二类)新药开发的临床前研究,广东省科技计划专项(重点)项目,编号:2004A30103003,经费: 30万元。7、2005、10—2007、12:血脉舒复方防治糖尿病肾病的新药开发研究,广州市科技计划专项(重大专项分题)项目,编号:2005Z1——E0041,经费:30万元。 近年来发表的主要研究论文如下:1、Tian Lan,Weihua Liu,Xi Xie, Suowen Xu, Kaipeng Huang, Jing Peng, Xiaoyan Shen, Peiqing Liu, Lijing Wang, Pu Xia, Heqing Huang(通讯作者). Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells. Molecular Endocrinology. ME-11-0095(2011) , [Epub ahead of print] (IF: 4.889)2、Qin Jiang , Peiqing Liu , Xiaoqian Wu, Weihua Liu, Xiaoyan Shen, Tian Lan, Suowen Xu, Jing Peng, Xi Xie, Heqing Huang(通讯作者). Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: Involvement of NF-kappaB signaling pathway. Molecular and Cellular Endocrinology, 331(2011)34-40 (IF: 4.119)3、Tian Lan, Huichang Bi, Weihua Liu, Xi Xei, Suowen Xu, Heqing Huang(通讯作者). Simultaneous determination of sphingosine and sphingosine 1-phosphate inbiological samples by liquid chromatography–tandem mass spectrometry. Journal of Chromatography B, 879(2011)520-526 (IF: 2.971)4、Xi Xie, Wenyuan Li, Tian Lan, Weihua Liu Jing Peng, Kaipeng Huang, Juan Huang,Xiaoyan Shen, Peiqing Liu1and Heqing Huang(通讯作者). Berberine ameliorates hyperglycemia in alloxan-induced diabetic C57BL/6 mice through activation of Akt signaling pathway. Endocrine Journal. 2011, 58(9), 761-768 (IF: 1.952)5、Fu-Tian Tang , Yuan Cao , Tie-Qiao Wang , Li-Jing Wang , Jiao Guo , Xiao-Shi Zhou , Suo-wen Xu ,Wei-Hu Liu , Pei-Qing Liu , He-Qing Huang(通讯作者) . Tanshinone IIA attenuates atherosclerosis in ApoE(-/-) mice through down-regulation of scavenger receptors expression. European Journal of Pharmacology, 650(2011 )275-284 (IF: 2.737)6、Yan-Hui Deng, Deepa Alex, He-Qing Huang(通讯作者), Nan Wang,Nan Yu,Yi-Tao Wang,George P. H. Leung and Simon Ming-Yuen Lee1. Inhibition of TNF-alpha-mediated endothelial cell-monocyte cell adhesion and adhesion molecules expression by the resveratrol derivative, trans-3,5,4'-trimethoxystilbene. Phytother. Res,2011;25(3):451-7 (IF: 1.878)7、Hong Nie, Hui Zhang, Xiao-qi Zhang, Yong Luoe, Lan-zhen Meng,Zhen Yin, Jianyu Zhang, Kongyan Li, Ai-hua Xiong, Ling Zhong, Heqing Huang(通讯作者) and Wen-cai Ye.Relationship between HPLC fingerprints and in vivo pharmacological effects of a traditional Chinese medicine: Radix Angelicae Dahuricae. Natural Product Research,2011, 25(1):53–61(IF: 0.906)8、Shu Tang,Xiao-Yan Shen,He-Qing Huang,Suo-Wen Xu,Yang Yu,Changhua Zhou,Shao-Rui Chen,Kang Le,Yu-Hua Wang,and Pei-Qing Liu.Cryptotanshinone Suppressed Inflammatory Cytokines Secretion in RAW264.7 Macrophages through Inhibition of the NF-kappaB and MAPK Signaling Pathways. Inflammation. 2011;34(2):111-8 (IF: 1.777)9、Tian Lan, Xiaoyan Shen,Peiqing Liu,Weihua Liu, Suowen Xu , Xi Xie, Qin Jiang, Wenyuan Li, Heqing Huang(通讯作者). Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway. Archives of Biochemistry and Biophysics,502(2010)112-120 (IF: 3.022)10、Weihua Liu, Xiaoyan Zhang, Peiqing Liu,Xiaoyan Shen,Tian Lan, Wenyuan Li, Qin Jiang, Xi Xie, Heqing Huang(通讯作者). Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury.European Journal of Pharmacology, 638(2010)150-155 (IF: 2.737)11、Tian Lan, Huichang Bi, Suowen Xu, Kang Le, Zhiyong Xie, Yiwei Liu and Heqing Huang (通讯作者). Determination of sphingosine kinase activity in biological samples by liquid chromatography-tandem mass spectrometry. Biomed Chromatogr,2010 ,24:1075-1083 (IF: 1.545)12、XiaoqianWu, Heqing Huang, Futian Tang, Kang Le, Suowen Xu, Peiqing Liu. Regulate13、Xuejuan Li, Weihua Liu, Qin Wang, Peiqing Liu, Yanhui Deng , Tian Lan, Xiaoyan Zhang, Biaoming Qiu, Hairong Nie, Heqing Huang(通讯作者). Emodin suppresses cell proliferation and FN expression via p38MAPK pathway in rat mesangial cells cultured under high glucose. Molecular and Cellular Endocrinology, 307(2009)157-162 (IF: 3.503)14、Weihua Liu, Futian Tang, Yanhui Deng , Xuejuan Li , Tian Lan, Xiaoyan Zhang ,Heqing Huang (通讯作者), Peiqing Liu. Berberine reduces fibronectin and collagen accumulation in rat glomerular mesangial cells cultured under high glucose condition.Molecular and Cellular Biochemistry ,(2009)325:99-105 (IF: 1.896)15、Weihua Liu, Peiqinq Liu, Sha Tao, Yanhui Deng , Xuejuan Li , Tian Lan, Xiaoyan Zhang , Fenfen Guo, Fengying Chen, Heqing Huang (通讯作者), Shufeng Zhou. Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose, Archives of Biochemistry and Biophysics, 475(2008):128-134 (IF: 2.626)16、LIU Wei-hua, HEI Zi-qing, NIE Hong, TANG Fu-tian, HUANG He-qing(通讯作者), LI Xue-juan, DENG Yan-hui, CHEN Shao-rui, GUO Fen-fen, HUANG Wen-ge, CHEN Feng-ying and LIU Pei-qing . Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase. Chinese Medical Journal , 2008; 121(8):706-712 (IF:0.858)17、Z.-Q. Hei; X.-L. Gan; H-Q. Huang,G.-J.Luo, S.-R. Li, J.Cai. Protective effects of cromolyn sodium on intestinal ischaemia-reperfusion-triggered lung injury in rats.British Journal of naesthesia, 2007 98: 407-408 (IF: 2.948)18、Jingping Wang , Heqing Huang (通讯作者), Peiqing Liu, Futian Tang, Jia Qing, Wenge Huang, Fengying Chen, Fenfen Guo, Weihua Liu, Bing Yang. Inhibition of phosphorylation of p38 MAPK involves in protection of nephropathy by Emodin in diabetic rats. European Journal of Pharmacology, 553(2006):297-303 (IF:2.522)19、GAN Xiao-liang, HEI Zi-qing, Huang He-qing(通讯作者), CHEN Li-xin, LI Shang-rong and CAI Jun . Effect of astragalus membranaceus injection on the activity of the intestinal mucosal mast cells after hemorrhage shock-reperfusion in rats. Chinese Medical Journal, 2006;119(22):1892-1898 (IF:0.615)20、Si-Gui Zhou, Shu-Feng Zhou, He-Qing Huang, Jian-Wen Chen, Min Huang, andPei-Qing Liu. . Proteomic Analysis of Hypertension-Induced Left Ventricular Hypertrophy by Two-Dimensional Difference Gel Electrophoresis and Mass Spectrometry. Journal of Proteome Research, 2006,5(11):2901-2908 (IF: 6.920)21、Zi-Qing Hei, He-Qing Huang (并列第一), Chen-Fang Luo, Shang-Rong Li. Changes of nitric oxide and endothelin, thromboxane A2 and prostaglandin in cirrhotic patients undergoing liver transplantation. World Journal of Gastroenterology, 2006 July 7; 12(25): 4049-4051 (IF :1.445)22、HEI Zi-qing, HUANG He-qing(通讯作者), TAN Hong-mei, LIU Pei-qing, ZHAO Ling-zhi, CHEN Shao-rui, HUANG Wen-ge, CHEN Feng-ying and GUO Fen-fen . Emodin inhibits atherosclerosis in rabbits with dietary perturbation and is associated with its the regulation of the sphingomyelin pathway. Chinese Medical Journal, 2006,119(10):868-870 (IF:0.615)23、Zi-Qing Hei, He-Qing Huang(通讯作者), Jing-Jun Zhang, Bing-Xue Chen. Protective effect of astragalus membranaceus of intestinal mucosa reperfusion injury after hemorrhagic shock in rats. World Journal of Gastroenterology, 28 (2005):4986-4991(IF:1.445)