皮荣标，博士、教授。1993年于江西中医学院获得药学学士学位，1999年于中山（医科）大学获得药理学硕士学位，2002年于中山大学医学院获得药理学博士学位。曾多次到境外，包括香港科技大学（2002）、新西兰奥克兰大学（2005）和美国耶鲁大学医学院（2009）开展博士后研究或合作研究。担任多个基金评审专家（包括国家自然科学基金面上项目、广东省自然科学基金和广州市科技局科技计划）、J Pharmaceutics 编委并在多个国内外重要学术刊物，如中山大学学报（医学版）、生物物理学学报、Chinese Medicine、Neuroscience、 Apoptosis、Biochimica et Biophysica Acta(BBA) -Molecular Basis of Disease、Eur J Med Chem、BMC Lett及J Alzheimer Dis等担任特邀审稿人。是中国药理学学会会员、中国神经科学学会会员和广东省“千百十”人才校级培养对象。主要从事神经药理学和分子神经生物学研究。主持国家自然科学基金与香港研究资助局联合项目、国家自然科学基金(2项)、科技部中意联委科技合作项目、广东省科技计划和广东省自然科学基金项目；参加多项包括科技部重大新药创制专项在内的国家级、省级研究项目。近年在J Biol Chem、J Neurochem、Br J Pharmacol、PLoS ONE、Neurochem Int、Toxicol Lett、Brain Res和Neurosci Lett等杂志发表论文近60篇，其中40余篇SCI论文。论文他引次数650余次。申请国家发明专利4项，授权1项。培养硕士研究生7名，已毕业3名。 联系方式：地址：广东省广州市大学城外环东路132号 中山大学药学院 邮编：510006电话：020-39943122；电子邮箱：pirb@mail.sysu.edu.cn 研究兴趣: 1. 中枢神经系统重大疾病（如脑缺血和阿尔茨海默氏病等）的分子机制； 2. 治疗神经系统疾病的“单分子多靶点”药物的研究开发。 讲授课程：本科生：药理学，药理学实验，中药药理学，药膳学，药物发展史 研究生：分子药理学，药理学进展，科研概论，治疗重大疾病药物研究进展，中药药理学，细胞培养 主持的科研项目：1. 国家自然科学基金：Nrf2/ARE的新功能——促进海马成体神经发生及其BDNF依赖性机制。№31371070，2014.1-2017.12；2. 科技部中意科技联委2013-2015项目：新型多靶点抗阿尔茨海默氏病药物的开发。№ MAE-M00705\CN13MO9，2013.1-2015.12；3．广东省科技计划国际合作项目：新型多靶点抗阿尔茨海默氏病候选药物的开发研究。№ 2012B050300015，2013.1-2014.12；4. 高等学校基本科研业务费. 新型化合物ZSU07012多靶点抗阿尔茨海默氏病作用研究。高校基本科研业务费中山大学青年教师培育项目，2010.6-2013.6，№ 10ykpy23。5．国家自然科学基金与香港研究资助局联合项目：新型他克林 - 米诺环素二聚体：多靶点防治老年性痴呆症的分子机制及其结构优化(大陆方负责人)；№ 30731160617，2008.1-2010.12;已发表的研究文章 (*通讯作者):1．Huang Y, Qin J, Chen M, Chao X, Chen Z, Ramassamy C, Pi R, Jin M. Lithium Prevents Acrolein-Induced Neurotoxicity in HT22 Mouse Hippocampal Cells. Neurochem Res. 2014 Feb 13. [Epub ahead of print] PubMed PMID: 24522749.2. Chen X, Gao J, Jiang Y, Huang P, Xie Y, Pi R, Zhu S, Yao M. Determination of newly synthesized lipoic acid-niacin dimer in rat plasma by UPLC/electrospray ionization tandem mass spectrometry: assay development, validation and application to a pharmacokinetic study. Biomed Chromatogr. 2014 Feb;28(2):213-7.3. Ouyang Y, Chen Z, Tan M, Liu A, Chen M, Liu J, Pi R, Fang J. Carvedilol, a third-generation β-blocker prevents oxidative stress-induced neuronal death and activates Nrf2/ARE pathway in HT22 cells. Biochem Biophys Res Commun. 2013 Nov 29;441(4):917-22.4. Daqian Zhu, Qi Liu, Bingling Luo, Meihui Chen, Rongbiao Pi, Peng Huang, Shijun Wen. Synthesis of Carbazoles via One-Pot Copper-Catalyzed Amine Insertion into Cyclic Diphenyleneiodoniums as a Strategy to Generate a Drug-Like Chemical Library. Advanced Synthesis & Catalysis. 2013，355（11-12）2172–2178. 5. Tan M, Ouyang Y, Jin M, Chen M, Liu P, Chao X, Chen Z, Chen X, Ramassamy C, Gao Y*, Pi R*. Downregulation of Nrf2/HO-1 pathway and activation of JNK/c-Jun pathway are involved in homocysteic acid-induced cytotoxicity in HT-22 cells. Toxicol Lett. 2013 Aug 27;223(1):1-8.6. Zhu D, Chen M, Li M, Luo B, Zhao Y, Huang P, Xue F, Rapposelli S, Pi R*, Wen S*. Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity. Eur J Med Chem. 2013 Aug 9;68C:81-88.7. Zhao ZM, Sun ZH, Chen MH, Liao Q, Tan M, Zhang XW, Zhu HD, Pi RB, Yin S. Neuroprotective polyhydroxypregnane glycosides from Cynanchum otophyllum. Steroids.2013 Oct;78(10):1015-20.8. Jiang Y, Zou Y, Chen S, Zhu C, Wu A, Liu Y, Ma L, Zhu D, Ma X, Liu M, Kang Z, Pi R, Peng F, Wang Q, Chen X. The anti-inflammatory effect of donepezil on experimental autoimmune encephalomyelitis in C57 BL/6 mice. Neuropharmacology. 2013 Oct;73:415-24.9. Jiang Y, Wu A, Zhu C, Pi R, Chen S, Liu Y, Ma L, Zhu D, Chen X. The protective effect of berberine against neuronal damage by inhibiting matrix metalloproteinase-9 and laminin degradation in experimental autoimmune encephalomyelitis. Neurol Res. 2013 May;35(4):360-8.10. Huang Y, Jin M, Pi R*, Zhang J, Chen M, Ouyang Y, Liu A, Chao X, Liu P, Liu J,Ramassamy C, Qin J*. Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Neurosci Lett.2013 Feb 22;535:146-51.11. Huang YJ, Jin MH, Pi RB*, Zhang JJ, Ouyang Y, Chao XJ, Chen MH, Liu PQ, Yu JC, Ramassamy C, Dou J, Chen XH, Jiang YM, Qin J*. Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo. Toxicol Lett. 2013 Mar 13;217(3):184-91.12. Zhao ZY, Luan P, Huang SX, Xiao SH, Zhao J, Zhang B, Gu BB, Pi RB, Liu J. Edaravone protects HT22 neurons from H2O2-induced apoptosis by inhibiting the MAPK signaling pathway. CNS Neurosci Ther. 2013 Mar;19(3):163-9.13. Chen X, Chen S, Jiang Y, Zhu C, Wu A, Ma X, Peng F, Ma L, Zhu D, Wang Q, Pi R. Minocycline reduces oxygen-glucose deprivation-induced PC12 cell cytotoxicity via matrix metalloproteinase-9, integrin β1 and phosphorylated Akt modulation. Neurol Sci. 2013 Aug;34(8):1391-6.14. Yu SS, Cai Y, Ye JT, Pi RB, Chen SR, Liu PQ, Shen XY, Ji Y. Sirtuin 6 protects cardiomyocytes from hypertrophy in vitro via inhibition of NF-κB-dependent transcriptional activity. Br J Pharmacol. 2013 Jan;168(1):117-28.15. Doggui S, Belkacemi A, Paka GD, Perrotte M, Pi R, Ramassamy C. Curcumin protects neuronal-like cells against acrolein by restoring Akt and redox signaling pathways. Mol Nutr Food Res. 2013 Sep;57(9):1660-70.16.王观峰，姚敏，李文立，邹秀兰，邹玉平，皮荣标. 硫辛酸烟酸二联体对丙烯醛损伤ARPE-19细胞的保护作用[J]. 眼科新进展,2013,02:106-109.17. Huang WY, Chao XJ, Ouyang Y, Liu AM, He XX, Chen MH, Wang LH, Liu J, Yu SW, Rapposelli S, RB Pi*. Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells. CNS Neurosci Ther. 2012 Nov;18(11):950-1.18. Chao X, He X, Yang Y, Zhou X, Jin M, Liu S, Cheng Z, Liu P, Wang Y, Yu J, Tan Y, Huang Y, Qin J, Rapposelli S, RB Pi*. Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6498-502.19. Xiao O, Xie ZL, Lin BW, Yin XF, RB Pi*, Zhou SY*. Minocycline inhibits alkali burn-induced corneal neovascularization in mice. PLoS One. 2012;7(7):e41858.20. Chen X, Ma L, Jiang Y, Chen S, Zhu C, Liu M, Ma X, Zhu D, Liu Y, Peng F, Wang Q, Pi R. Minocycline up-regulates the expression of brain-derived neurotrophic factor and nerve growth factor in experimental autoimmune encephalomyelitis. Eur J Pharmacol. 2012 Jul 5;686(1-3):124-9.21. Xuexuan Mao, Jiaotao Ye, Shiyou Zhou, Rongbiao Pi*, Juan Dou, Lingquan Zang, Xiaojuan Chao, Xiaohong Chen, Wenming Li, Mengfei Liu, Peiqing Liu. The effects of chronic copper exposure on the amyloid protein metabolisim associated genes' expression in chronic cerebral hypoperfused rats. Neurosci Lett. 2012. Jun 14;518(1):14-8.22. Cai Y, Yu SS, Chen SR, Pi RB, Gao S, Li H, Ye JT, Liu PQ. Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6. FEBS Lett. 2012 Mar 23;586(6):866-74.23. Pi R*, Mao X, Chao X, Cheng Z, Liu M, Duan X, Ye M, Chen X, Mei Z, Liu P, Li W*, Han Y*. Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo. PLoS One. 2012;7(2):e31921.24. Zhang H, Mak S, Cui W, Li W, Han R, Hu S, Ye M, Pi R*, Han Y*. Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway. Neurochem Int. 2011 Dec;59(7):981-8.25. Mao X, Yin W, Liu M, Ye M, Liu P, Liu J, Lian Q, Xu S, Pi R*. Osthole, a natural coumarin, improves neurobehavioral functions and reduces infarct volume and matrix metalloproteinase-9 activity after transient focal cerebral ischemia in rats. Brain Res. 2011 Apr 18;1385:275-80.26. Ma X, Jiang Y, Wu A, Chen X, Pi R, Liu M, Liu Y. Berberine attenuates experimental autoimmune encephalomyelitis in C57 BL/6 mice. PLoS One. 2010 ;5(10):e13489.27. Mei Liu, Xiaomeng Ma, Xiaohong Chen, Ying Jiang, Aimin Wu, Fuhua Peng, Yingying Liu, Rongbiao Pi. Ischemic preconditioning partially suppresses andpostpones integrin αVβ3 mRNA expression followingtransient global cerebral ischemia in C57BL/6mice. Neural Regen Res. 2010;5(23):1782-1786.28. Xiaohong Chen, Rongbiao Pi, Yan Zou, Xueqiang Hu, Mei Liu, Xiaomeng Ma, Xuexuan Mao. Attenuation of experimental autoimmune encephalomyelitis in C57 BL/6 mice by osthole, a natural coumarin. Eur J Pharmcol. 2010; 629(1-3):40-6.29. Xiao-hong Chen, Zhu-zhen Lin, An-min Liu, Jian-tao Ye, Yan Luo, Yu-yan Luo, Xue-xuan Mao, Pei-qing Liu, Rong-biao Pi*. The orally combined neuroprotective effects of sodium ferulate and borneol against transient global ischemia in C57 BL/6J mice. J Pharm Pharmacol. 2010, 62(7): 1–9.30. Xiaohong Chen, Rongbiao Pi, Mei Liu, Xiaomeng Ma, Ying Jiang, Aimin Wu, Xuexuan Mao, Xueqiang Hu. Minocycline ameliorates experimental autoimmune encephalomyelitis in C57 BL/6 mice through up-regulating the expression of BDNF and NGF. J Neuroimmunol. 2010, 226(1-2):104-9.31. Ye JT, Pi RB*(co corresponding author), Mao XX, Chen XH, Qin J, Xu SW, Liu PQ. Alterations in mRNA expression of BACE1, cathepsin B, and glutaminyl cyclase in mice ischemic brain. Neuroreport. 2009; 20(16):1456-60.32. Chen X, Hu X, Zou Y, Pi R, Liu M, Wang T, Zheng X, Liu M, Lin M, Liu P, Tao L. Combined treatment with minocycline and prednisone attenuates experimental autoimmune encephalomyelitis in C57 BL/6 mice. J Neuroimmunol. 2009; 210(1-2):22-9.33. Mei Z, Zhang F, Tao L, Zheng W, Cao Y, Wang Z, Tang S, Le K, Chen S, Pi R*(co corresponding author), Liu P. Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro. Neurosci Lett. 2009; 452(2):90-5.34. Chen X, Lan X, Mo S, Qin J, Li W, Liu P, Han Y, Pi R*. p38 and ERK, but not JNK, are involved in copper-induced apoptosis in cultured cerebellar granule neurons. Biochem Biophys Res Commun. 2009; 379(4):944-8.35. Zhang F, Zheng W, Pi R, Mei Z, Bao Y, Gao J, Tang W, Chen S, Liu P. Cryptotanshinone protects primary rat cortical neurons from glutamate-induced neurotoxicity via the activation of the phosphatidylinositol 3-kinase/Akt signaling pathway. Exp Brain Res. 2009; 193(1):109-18.36. 刘梦菲, 阮志, 皮荣标*, 新靶点谷氨酰胺酰基环化酶治疗阿尔茨海默病的新进展. 中国药学杂志, 2009；36(13):240-244.37. RZ Lin, XH Chen, WM LI, YF Han, PQ Liu, RB Pi*. Effects of metal ions on the expression of APP and BACE1 in PC12 cells: Blocking by Curcumin. Neurosci Lett，2008；440（3）:344-347.38. 蓝秀健，叶敏忠，刘培庆，余剑平，皮荣标*. 铜对低钾诱导大鼠小脑颗粒神经元凋亡的保护. 中山大学学报（医学版）. 2008；29（2）：154-158.39. 林竹贞, 蓝明雄, 姚美村, 钟国平, 刘培庆，皮荣标*. 冰片对阿魏酸钠在小鼠血浆和脑区中分布的影响.中草药. 2008; 39（4）：551-556.40. Janusz Lipski, Carthur K Wan, Ji-Zhong Bai, Rongbiao Pi, Dong Li, David F Donnelly. Neuroprotective potential of ceftriaxone in in vitro models of stroke. Neuroscience, 2007；146(2):617-29.41. Wenming Li, Rongbiao Pi, Hugh H.N. Chan, Hongjun Fu, Nelson T.K. Lee, Hing Wai Tsang, Yongmei Pu, Donald C. Chang, Jialie Luo, Keming Xiong, Zhiwang Li, Chaoying Li, Hong Xue, Paul R. Carlier, Yuanping Pang, Karl W.K. Tsim, Mingtao Liand Yifan Han. Novel Dimeric AChE Inhibitor Bis(7)-tacrine, but not Donepezil, Prevents Glutamate-induced Neuronal Apoptosis by Blocking NMDA Receptors. J Biol Chem, 2005, 280(18):18179-88.42. Rongbiao Pi, Wenming Li, Nelson T.K. Lee, Hugh H.N. Chan, Yongmei Pu, Ling Nga Chan, Nikolaus J Sucher, Donald C. Chang, Mingtao Li, Yifan Han. Minocycline Prevents Glutamate-induced Apoptosis of Cerebellar Granule Neurons by Differential Regulation of p38 and Akt Pathways. J. Neurochem,2004, 91(5): 1219-1230.43. Rongbiao Pi, Wei Yin, Suqiu Zheng, Pengxin Qiu, Jian Zhou, Wei Guo, Tao Su, and Guangmei Yan. Adenoviral mediated transfer of TIMP-3 partially prevents glutamate-induced cell death in primary cultured cortical neurons of the rat. Brain Res Mol Brain Res, 2004, 127(1-2): 136-139. 已发表综述（*通讯作者）：1. Ronggui Guan, Xiaoyu Xu, Meihui Chen, Haiyan Hu, Hu Ge, Shijun Wen*, Shiyou Zhou*, Rongbiao Pi*. Advances in the Studies of Roles of Rho/Rho-kinase in Diseases and the Development of Its Inhibitors. Eur J Med Chem. 2013 Dec;70:613-22.2. Chen M, Liu A, Ouyang Y, Huang Y, Chao X, Pi R*. Fasudil and its analogs: a new powerful weapon in the long war against central nervous system disorders? Expert Opin Investig Drugs. 2013 Apr;22(4):537-50.3. 陈美惠，刘安民，巢晓娟，皮荣标*. Rho激酶抑制剂法舒地尔对中枢神经系统疾病作用及其结构改造的研究进展[J]. 中国新药杂志,2013,01:59-67.4. 董雪姣，姜伊鸣，于暕辰，皮荣标*. 川芎嗪衍生物及其药理活性研究进展[J]. 中南药学,2012,04:294-299.5. Chen X, Ma X, Jiang Y, Pi R, Liu Y, Ma L. The prospects of minocycline in multiple sclerosis. J Neuroimmunol. 2011 Jun;235(1-2):1-8. Epub 2011 May 11.6. Ye M, Fu S, Pi R*, He F. Neuropharmacological and pharmacokinetic properties of berberine: a review of recent research. J Pharm Pharmacol. 2009; 61(7):831-7.7. 刘梦菲，阮志，皮荣标*. 新靶点谷氨酰胺酰基环化酶治疗阿尔茨海默病的新进展[J]. 中国药学杂志,2009,13:965-967.8. 徐海侠，谢琦，皮荣标. 阿尔茨海默病淀粉样斑块的活体MR可视化成像研究进展. 国际医学放射学杂志. 2009; 32(6):529-532.9. 叶敏忠，成志毅，皮荣标*. 基于他克林的多靶位乙酰胆碱酯酶抑制剂的研究进展. 中国药理学通报；2008；24（12）：1145-1149.10. 叶敏忠，成志毅，皮荣标*. “杂交”与“桥联”——以他克林衍生物为代表探讨开发多靶点抗阿尔茨海莫氏病药物的新策略[A]. 中国药理学会.药学发展前沿论坛及药理学博士论坛论文集[C].中国药理学会:,2008:12.11. 纳鑫, 汪雪兰, 皮荣标*. 川芎嗪的中枢神经药理作用研究进展，中国中药与临床药理杂志. 2008; 19（1）：77-80。12.毛雪璇，皮荣标*. Morris水迷宫影响因素新进展. 中国行为科学杂志，2008,17(8):152-154.13. 林竹贞，皮荣标*. 啮齿类脑缺血动物模型的研究进展. 中国神经精神疾病杂志，2007，33（9）：574-576.14. 李莹莹，蓝秀建，朱振宇，皮荣标*. 鱼藤酮诱导的帕金森病动物模型的研究进展. 中南药学. 2007; 5(1):52-56.15. 蓝秀建，李莹莹，叶敏忠，皮荣标. 肝豆状核变性中的神经系统变性与铜毒性的综述. 中山大学学报论丛. 2007, 27(3):182-187. 国家发明专利：1．皮荣标, 林竹贞, 等. 一种防治缺血性脑血管疾病的药物复合物及其制备方法. 专利号: ZL 2007 1 0031777.42．皮荣标, 叶敏忠, 等, 他克林——阿魏酸杂联体，其制备方法及其药物组合物物。国家发明专利申请号：200810028558.5。3．皮荣标；巢晓娟；何细新；成志毅；阳怡林；韩怡凡；李文明；毛雪璇；叶敏忠；陈晓红；叶建涛；刘培庆。他克林-咖啡酸杂联体，其制备方法及其药物组合物。国家发明专利申请号：201110359965.6.4．皮荣标；姜伊鸣；颜金武；巢晓娟；刘培庆；黄燕；姚美村；何细新. 烟酸衍生物,其制备方法及其药物组合物. 国家发明专利申请号：201110430852.0