1984年本科毕业于上海医科大学（现为复旦大学上海医学院）医学系并在附属华山医院任临床医生。1994年获荷兰Leiden大学免疫学博士；1999年被瑞典国家研究院（VR/MFR）聘为助理教授。2004年获国家杰出青年基金，2009年被聘为教育部“长江学者”特聘教授。现任中山大学; 肿瘤医院生物治疗中心主任；生命科学院副院长；中山大学肝癌研究所所长。多年来一直从事调控人免疫细胞功能的机制研究，在国际期刊发表论文60余篇，总影响因子350余点。回国后，以肝癌为主要模型，研究间质免疫细胞与癌细胞之间的相互作用和潜在机制，探讨以间质细胞作为肿瘤分子分期和治疗靶标的可行性。先后获国家杰出青年基金、基金委重点项目（2007和2012）、科技部“973”计划和卫生部重大专项（“十一五”和“十二五”）等资助。作为通讯作者的论文已于近年发表在J. Exp. Med., Hepatology和Blood 等知名期刊。培养的研究生于2011年获“全国百篇优秀博士论文”主要研究方向为：巨噬细胞生物学；肿瘤微环境与免疫编辑；肿瘤分子分型和免疫治疗。我们以临床样本为基础，结合体外和体内实验模型，主要开展以下三个方面的工作：1. 以单核巨噬细胞为核心，系统研究肿瘤微环境对免疫细胞分化与表型的调控机制，以及免疫微环境对肿瘤血管生成和转移的影响与机制。2. 综合评价肝癌组织免疫状态对临床转归的影响；建立可用于临床判断肝癌进展/预后的预测模型；并探讨进行个体化免疫干预的可行性。3. 以MDSC为模型，研究肿瘤对造血干细胞分化、以及组织微环境对MDSC形成和扩增的调控和机制。 详见实验室网页：Homepage: http://home.sysu.edu.cn/limingroup/en近年发表的十篇代表性论文：1. Y Wu, DM Kuang, WD Pan, Y Wan, X Lao, D Wang, XF Li, and L Zheng. Monocyte /Macrophage-elicited NK cell dysfunction in Hepatocellular carcinoma is mediated by CD48/2B4 interactions. Hepatology. 2013, 57:1107-16.2. J Xu, T Ding, Q He, X Yu, W Wu, W Jia, J Yun, Y Zhang, M Shi, C Shao, WD Pan, X Yin, J Min, SM Zhuang and L Zheng. In Situ molecular signature predict early recurrence in Hepatitis B virus-related hepatocellular carcinoma. J. Hepatol. 2012, 57:313-21.3. Q Zhao, DM Kuang, Y Wu, X Xiao, X Li, T Li, and L Zheng. Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages. J. Immunol. 2012, 188:1117-24.4. DM Kuang, Q Zhao, Y Wu, C Peng, J Wang, Z Xu, XY Yin, and L Zheng. Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. J. Hepatol. 2011, 54:948–55.5. T Ding, J Xu, Y Zhang, R Guo, W Wu, S Zhang, CN Qian, and L Zheng. Endothelium coated tumor clusters are associated with poor prognosis and micrometastasis of hepatocellular carcinoma after resection. Cancer. 2011, 117:4878-89.6. DM Kuang, C Peng, Q Zhao, Y Wu, LY Zhu, J Wang, XY Yin, and L Zheng. Tumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients. J. Immunol. 2010, 185:1544-9. 7. DM Kuang, C Peng, Q Zhao, Y Wu, MS Chen, and L Zheng. Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory Th17 cells. Hepatology. 2010, 51:154-64.8. DM Kuang, QY Zhao, C Peng, J Xu, JP Zhang, C Wu, and L Zheng. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J. Exp. Med. 2009, 206: 1327-37.9. JP Zhang, J Yan, J Xu, XH Pang, MS Chen, L Li, C Wu, SP Li, and L Zheng. Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J. Hepatol. 2009, 50:980-9.10. DM Kuang, Y Wu, N Chen, J Cheng, SM Zhuang, and L Zheng. Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes. Blood. 2007, 110:587-95.