姓 名：侯廷军 职称职务：教授、博士生导师 联系电话： 电子邮箱：tingjunhou@zju.edu.cn 办公地址：浙江大学紫金港校区药学院个人简介一．学习工作经历1、学历背景：1992年至1997年：北京大学化学学士1997年至2002年：北京大学理学博士2、工作经历：2002年至2004年：北京大学化学系，博士后2004年至2008年：美国加州大学圣地亚哥分校，博士后和项目研究员2009年至2012年：苏州大学功能纳米与软物质研究院/药学院，教授、博士生导师2013年3月至今：浙江大学药学院，教授、博士生导师。二. 研究方向主要研究方向包括：(1). 计算机辅助药物分子设计方法研究；(2). 蛋白质/多肽以及蛋白质/蛋白质相互作用网络预测方法研究；(3). 激酶家族重要靶点的药物分子设计；(4). 基于传统中药资源的药物分子设计研究。三. 主要研究成果(1). 学术成果简介长期致力于计算机辅助药物分子设计关键技术和应用的研究，发展的方法、模型和程序被国际知名分子模拟软件系统、大型制药公司和国内外同行广泛采用。主要成果包括：(1)对分子间相互作用计算中的若干核心问题进行了深入和系统的理论研究，发展了多种基于分子间相互作用计算的蛋白结构域-多肽相互作用预测方法和抗病毒药物耐药性预测模型；(2) 发展了一系列药代动力学重要性质和成药性的预测方法和模型。在PNAS, DDT, Mol Pharmaceutics, Mol Cell Proteomics, J Proteome Res, PLoS Comput Biol, Mol Cancer Therapeutics，J Med Chem, J Chem Inf Model等SCI收录期刊上发表论文160余篇，总影响因子超过450，他引超过1800次，H因子为30。自计算机辅助药物分子设计和化学信息学领域最具影响力的专业性期刊J Chem Inf Model创刊50年以来，在该期刊上发表论文数排名全世界第24位 (共26篇)，华人第1位。(2). 近期代表性论文.1. Lei Xu, Youyong Li, Huiyong Sun, Xuechu Zhen, Chunhua Qiao, Sheng Tian, Tingjun Hou*, Current developments of macrophage migration inhibitory factor (MIF) inhibitors, Drug Discovery Today, 2013, in press.2. Lei Chen, Youyong Li, Huidong Yu, Liling Zhang, Tingjun Hou*, Computational models for predicting substrates and inhibitors of P-glycoprotein, Drug Discovery Today, 2012, 17, 343-351.3. Lin Li, Youyong Li, Liling Zhang, Tingjun Hou*, Theoretical studies on the susceptibility of oseltamivir against variants of 2009 A/H1N1 influenza neuraminidase, Journal of Chemical Information and Modeling, 2012, 52, 2715-2729.4. Sheng Tian, Junmei Wang, Youyong Li, Xiaojie Xu, Tingjun Hou*, Drug-likeness analysis of Traditional Chinese Medicines: prediction of drug-likeness using machine learning approaches, Molecular Pharmaceutics, 2012, 9, 2875-2886.5. Dongyue Cao, Junmei Wang, Rui Zhou, Youyong Li, Huidong Yu, Tingjun Hou*, ADMET evaluation in drug discovery. 11. PharmacoKinetics Knowledge Base (PKKB) - a comprehensive database of pharmacokinetic and toxic properties for drugs, Journal of Chemical Information and Modeling, 2012, 52, 1132-1137.6. Yinxiang Wei, YuanFang Ma, Qing Zhao, Zhiguang Ren, Yan Li, Tingjun Hou*, Hui Peng*, New use for an old drug: inhibiting ABCG2 with sorafenib, Molecular Cancer Therapeutics, 2012, 11, 1693-1702.7. Tingjun Hou*, Nan Li, Youyong Li, Wei Wang*, Characterization of domain-peptide interaction interface: prediction of SH3 domain-mediated protein-protein interaction network in yeast by generic structure-based models, Journal of Proteome Research, 2012, 11, 2982-2995.8. Sichao Wang, Youyong Li, Junmei Wang, Lei Chen, Liling Zhang, Huidong Yu, Tingjun Hou*, ADME evaluation in drug discovery. 12. development of binary classification models for prediction of hERG potassium channel blockage, Molecular Pharmaceutics, 2012, 9, 996-1010.9. Junmei Wang*, Tingjun Hou*, Application of molecular dynamics simulations in molecular property prediction II: diffusion coefficients, Journal of Computational Chemistry, 2011, 32, 3505-3519.10. Junmei Wang*, Tingjun Hou*, Application of molecular dynamics simulations in molecular property prediction I: density and heat of vaporization, Journal of Chemical Theory and Computation, 2011, 7, 2151-2165.11. Sheng Tian, Youyong Li, Junmei Wang, Jian Zhang*, Tingjun Hou*, ADME evaluation in drug discovery. 9. prediction of oral bioavailability in human based on molecular properties and structural fingerprints, Molecular Pharmaceutics, 2011, 8, 841-851.12. Tingjun Hou*, Youyong Li, Wei Wang*, Prediction of peptides binding to the PKA RIIα subunit using a hierarchical strategy, Bioinformatics, 2011, 27, 1814-1821.13. Lei Chen, Youyong Li, Qin Zhao, Hui Peng*, Tingjun Hou*, ADME evaluation in drug discovery. 10. predictions of P-glycoprotein inhibitors using recursive partitioning and naïve Bayesian classification techniques, Molecular Pharmaceutics, 2011, 8, 889-900.14. Tingjun Hou*, Junmei Wang, Youyong Li, Wei Wang*,Assessing the performance of the MM/PBSA and MM/GBSA methods: I. The accuracy of binding free energy calculations based on molecular dynamics simulations, Journal of Chemical Information and Modeling, 2011, 51, 69-82.15. Tingjun Hou*, Junmei Wang, Youyong Li, Wei Wang*, Assessing the performance of the Molecular Mechanics/Poisson Boltzmann Surface Area and Molecular Mechanics/ Generalized Born Surface Area methods. II. the Accuracy of ranking poses generated from docking, Journal of Computational Chemistry, 2011, 32, 866-877.16. Jing Zhang#, Tingjun Hou# (Co-first author), Wei Wang, Jun S. Liu, Detecting and understanding combinatorial mutation patterns responsible for HIV drug resistance, Proceedings of the National Academy of Sciences, 2010, 107, 1321-1326.17. Tingjun Hou, Zheng Xu, Wei Zhang, William A. McLaughlin, David A. Case, Yang Xu, Wei Wang, Characterization of domain-peptide interaction interface: a generic structure-based model to decipher the binding specificity of SH3 domains, Molecular & Cellular Proteomics, 2009, 8, 639-649.18. Tingjun Hou* , Junmei Wang, Wei Zhang, Xiaojie Xu, ADME evaluation in drug discovery. 7. prediction of oral absorption by correlation and classification. Journal of Chemical Information and Modeling. 2007, 47, 208-218.19. Tingjun Hou*, Yon Yu, Molecular dynamics and free energy studies on the wild-type and double Mutant HIV-1 protease complexed with amprenavi and two amprenavir-related inhibitors: mechanism for binding and drug resistance, Journal of Medicinal Chemistry, 2007, 50, 1177-1188.20. Tingjun Hou*, Junmei Wang, Wei Zhang, Xiaojie Xu, ADME evaluation in drug discovery. 6. if the oral bioavailability in human can be effectively predicted by simple molecular properties-based rules? Journal of Chemical Information and Modeling, 2007, 47, 460-463.(3). 课题1. 973重大研究计划，纳米界面生物分子作用机制的基础研究及其在前列腺癌早期检测中的应用，2012~2016，参与。2. 高等学校博士学科点专项科研基金，药物分子代谢和毒性的预测研究，2013~2015，负责。3. 江苏省高校青蓝工程科技创新团队，肿瘤纳米技术，2012~2014，负责4. 国家自然科学基金面上项目，蛋白质结构域介导的蛋白一蛋白相互作用网络的研究，2012~2015，负责5. 国家自然科学基金面上项目，基于hERG钾离子通道的药物分子心脏毒性的预测, 2009~2012，负责(4). 著作1. 徐筱杰, 侯廷军, 乔学斌, 章威, 计算机辅助药物分子设计, 化学化工出版社, 2004 (负责超过2/3内容的撰写工作)2. 罗旭, 化学统计学, 科学出版社, 2002 , 编委 (第16章)3. Junmei Wang, Tingjun Hou, Chapter 5 Recent Advances on in silico ADME Modeling, Annual Reports in Computational Chemistry, Elsevier, Volume 5, 2009, 101-127.4. Tingjun Hou, Xu Xiaojie, Recent development and application of virtual screening in drug discovery: An Overview. in Frontier in Medicinal Chemistry, Bentham Science Publishers, Vol 3, 2006, 675-703.5. Molecular Conceptor courseware, Synergix Ltd. 2008. (Contributing the chapter: introduction to chemoinformatics).(5). 授权专利和软件著作权1. PharmacoKinetic Knowledge Base软件著作权2. 分子键型自动生成软件Fixbond软件著作权3. 基于分子表面的构象熵计算软件SASCEC软件著作权4. 3-[4-(磺酰)苯]脲类化合物及其在制备抗肿瘤药物中的应用（201110263951.4）四．主要荣誉2012，第四届青年科学之星，铜奖（生命科学领域）2012，江苏省高校青蓝工程科技创新团队负责人2011，江苏省第四期“333高层次人才培养工程”培养对象2010，苏州市紧缺高层次人才2008，全国高校自然科学二等奖（排名第2）2003，北京大学优秀博士论文2003，博士后科学基金一等资助金2000，北京大学研究生学术十杰2002，中国大学生建昊奖学金五．社会兼职中国化学会计算(机)化学专业委员会委员；Journal of Cheminformatics、Theoretical Biology & Medical Modelling、Genomics, Proteomics & Bioinformatics、Journal of Pharmaceutics编委；Current Pharmaceutical Design 、Mini-Reviews in Medicinal Chemistry、Current Computer-aided Drug Design、Medicinal Chemistry国际顾问编委；Combinatorial Chemistry & High Throughput Screening 客座编辑；DDT、J Med Chem、Mol Pharm、JACS、Antiviral Res、J Biol Chem、Bioinformatics、J Chem Inf Model、PLoS One等50多个期刊审稿人。