杨红枚,华中科技大学同济医学院基础医学院人才引进特聘教授、博士生导师。毕业于武汉大学病毒学专业;留学美国十年,先后在哈佛医学院和美国生物医药公司从事病毒免疫、蛋白质代谢和肿瘤生物学的研究及肿瘤治疗药物的研发。现任湖北省微生物学学会常务理事,微生物及免疫学会理事,国家自然科学基金委和教育部通讯评审专家等社会职务。共计发表科研论文30余篇,其中已被SCI收录近二十篇。主要论文: 1. Chen X, Han W, Ruan A, Zhao Y, Xu Z, Lu X, Yang H*, Zhang X*. miR-141 is A Key Regulator of Renal Cell Carcinoma Proliferation and Metastasis by Controlling EphA2 Expression. Clinical Cancer Research. 2014 ( IF:7.8,共同通讯作者)2. Yang H, Chen X, Wang X, Li Y, Chen S, Qian X, Wang R, Chen L, Han W, Ruan A, Du Q, Olumi AF, Zhang X*. Inhibition of PP2A Activity Confers a TRAIL-sensitive Phenotype During Malignant Transformation. Mol Cancer Res, Feb;12(2):217-27, 2014 ( IF:4.6,第一作者)3. Wang X. Chen X, Wang R, Xiao P, Xu Z, Chen L, Han W, Ruan A, Yang H*, Zhang X*. microRNA-200c modulates the epithelial-to-mesenchymal transition in human renal cell carcinoma metastasis. Oncol Rep,30(2): p. 643-50. 2013 ( IF:2.2,共同通讯作者)4. Hongmei Yang, Charles H. Lin, Gang Ma, Michael Baffi and Marc G. Wathelet Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions. FEBS J. (Eur. J. Biochem.); 269(24): 6142-51, 2002 Dec. 5. Hongmei Yang, Charles H. Lin, Gang Ma, Michael Baffi and Marc G. Wathelet Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators. J Biol Chem.; 278(18): 15495-504, 2003 May 2.6. Hongmei Yang, Gang Ma, Michael Baffi and Marc G. Wathelet. Mechanism for transcriptional synergy between interferon regulatory factor (IRF)-3 and IRF-7 in activation of the interferon-beta gene promoter. FEBS J. (Eur. J. Biochem.); 271(18): 3693-703, 2004 Sep.7. Hongmei Yang, Wei Wei , Michael Menconi, and Per-Olof Hasselgren. Dexamethasone-induced Protein Degradation in Cultured Myotubes is p300/HAT-dependent. Am I Physiol Regul Integr Comp Physiol.; 292(1):R337-4, 2007 Jan.8. Hongmei Yang, Joshua Mammen, Micahel Menconi, Per-Olof Hasselgren. Expression and Activity of C/EBPbeta and delta are Upregulated by Dexamethasone in Skeletal Muscle. J Cell Physiol.; 204(1): 219-26, 2005 July.9. Hongmei Yang, Mike Menconin, Per-Olof Hasselgren. Dexamethasone Upregulates the Expression of the Nuclear Cofactor p300 and its Interaction with C/EBP BETA in Cultured Myotubes. J Cell Biochem.; 94(5): 1058-67, 2005 Apr 1.10. Xiaoping Zhang, Liang Zhang, Hongmei Yang, Xu Huang, Hasan Otu, Towia A. Libermann,, William C. DeWolf, Roya Khosravi-Far, Aria F. Olumi. c-Fos as a Proapoptotic Agent in TRAIL-Induced Apoptosis in Prostate Cancer Cells. Cancer Res; 67(19): 9425-34,2007 Oct 1. 11. Wei Wei , Hongmei Yang , Peirang Cao , Michael Menconi, and Per-Olof Hasselgren. Treatment of Cultured Myotubes with the Proteasome Inhibitor β-lactone Increase the expression of the Transcription Factor C/EBP β. Am J Physiol Cell Physiol.; 292(1):C216-26, 2007 Jan.12. Wei Wei , Hongmei Yang, Peirang Cao , Michael Menconi, Petkova V, Hasselgren PO. Degradation of C/EBP β in cultured Myotubes is Calpain-dependent. J Cell Physiol.; 208(2): 386-98,2006 Aug.13. Hasselgren PO, Menconi MJ, Fareed MU, Yang H, Wei W, Evenson A. Novel aspects on the regulation of muscle wasting in sepsis. Int J Biochem Cell Biol. 2005 Oct;37(10):2156-68. Epub 2005 Mar 1314. Wei Wei, Fareed MU, Evenson A, Menconi MJ, Hongmei Yang , Petkova V, Hasselgren PO. Sepsis Stimulates Calpain Activity in Skeletal Muscle by Decreasing Calpastatin Activity but Does not Activate Caspase-3. Am J Physiol Regul Integr Comp Physiol. 2005 Mar; 288(3):R580-90.15. Xiaoping Zhang, Tai-Guang Jin, Hongmei Yang, William C. DeWolf, Roya Khosravi-Far and Aria F. Olumi. Persistent c-FLIP(L) Expression is Necessary and Sufficient to Maintain Resistance to Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated Apoptosis in Prostate Cancer. Cancer Res. 2004 Oct 1; 64(19): 7086-91. 16. Menconi MJ, Wei W, Hongmei Yang, Wray CJ, Hasselgren PO. Treatment of Cultured Myotubes with the Calcium Ionophore A23187 Increases Proteasome Activity via a CaMK II-caspase-calpain-dependent Mechanism. Surgery. 136(2): 135-42, 2004 Aug. 主要著作:杨红枚参编,《病毒转基因技术原理》。科学出版社,2014年。科研项目:1. MicroRNA-141调控HCV复制的机制研究,病毒学国家重点实验室开放课题,2014-2016年;2. 恶病质肌肉萎缩中Myostatin表达调控的机制研究,国家自然科学基金面上项目,2012-2015年;3. 病毒激活因子(VAF)调控丙型肝炎病毒诱导的干扰素表达机制的研究,国家自然科学基金面上项目,2011-2013年。4. 恶病质肌肉萎缩中Myostatin表达调控的机制研究,湖北省科技厅面上项目,2011-2012年;5. 丙型肝炎病毒感染的肝细胞对TRAIL敏感的机制研究,湖北省卫生厅科研一般项目,2011-2012年。6. HCV感染的肝细胞对TRAIL敏感的机制研究,华中科技大学自主创新研究基金资助项目,2010-2012年。