张勇慧,天然药物化学教授,博士生导师,药学院副院长,教育部“新世纪优秀人才支持计划”、“湖北省杰出青年基金”、“武汉市学科带头人”及“武汉市3551人才工程”获得者。主要从事天然药物生物活性成分及创新药物研究。中国中药和天然药物专业委员会委员,中国医药生物技术协会生物制药技术分会常务委员,湖北省药学会副秘书长、常务理事,湖北省中药和天然药物专业委员会主任委员,武汉市药学会副理事长,华中科技大学学术委员会医科分委会委员。国家科技奖励评审专家,教育部科技奖励评审专家,国家CFDA新药、化妆品审评专家,国家发改委药品价格评审专家、国家重大新药创制专项评审专家,国家重大新药创制专项“十二五”《糖尿病新药临床前研究》课题组长。湖北省药学一级重点学科负责人,中药学湖北省品牌专业负责人。课题组主持国家“重大新药创制”专项课题3项,国家高技术研究发展计划(863计划)1项,国家自然科学基金项目12项,及多项省市级科研项目及企业合作项目,总经费4000余万元。申请专利9项,发表学术论文篇100余篇, 其中SCI收录论文40余篇,副主编或参加编写国家级教材或配套教材8部。2012年获华中科技大学“青年五四奖章”,2011年获湖北省科技进步二等奖2008年被评为华中科技大学“十佳优秀青年教职工”,2006年获湖北省自然科学三等奖, 2005年被评为华中科技大学“优秀青年教职工”。(一)近年主持的科研项目2014.1-2016.12国家高技术研究发展计划(863计划)《促肝细胞再生金线莲胶囊保健品的研究与开发》625万元2014.1-2017.12国家自然科学基金《肉桂和川桂中抗肿瘤二萜化学成分及作用机制研究》80万元2013.1-2015.12 科技部中韩国际合作项目《化药一类降血糖新药KD10临床前研究》90万元2012.1-2014.12 武汉市3551人才项目《化药一类降血糖新药KD10临床前研究》100万元2011.1-2013.12国家重大新药创制专项课题《糖尿病新药临床前研究》2291万元2011.1-2013.12国家重大新药创制专项课题《中药6.1类治疗类风湿关节炎新药复方鹿角霜片临床前研究》150万元2011.1-2013.12国家自然科学基金《黄芫花中抗肿瘤二萜活性成分及抑制肿瘤侵袭转移作用机制研究》35万元2010.1-2012.12国家自然科学基金《虎尾轮根抗类风湿性关节炎的活性成分及作用机制研究》32万元2009.1-2011.12 教育部新世纪优秀人才支持计划《楮头红保护肝损伤的活性成分及作用机制研究》50万元2006.1-2008.12国家自然科学基金《浙贝乙素抑制HDAC的构效关系及机制》26万元2005.1-2007.12国家自然科学基金《金线莲中抑制IKK-β增敏胰岛素的活性成分及作用机制研究》22万元2007.1-2008.12教育部高等学校科技创新工程重大项目培育资金《中药一类新药浙贝乙素胆酸盐的研究》80万元 (二)近年发表的主要论文27. Mengke Zhang, Yangyang Xie, Guanqun Zhan, Liang Lei, Penghua Shu, Yongli Chen, Yongbo Xue, Zengwei Luo, Qian Wan, Guangmin Yao*, Yonghui Zhang *.Diterpenoids from the leaves of Rhododendron micranthum. Phytochemistry. 97(2014): (in press)26. Guoli Guo, Yao Guangmin,Yonghui Zhang*,Hudan Liu*.N-methylhemeanthidine chloride, a novel Amaryllidaceae alkaloid, inhibits pancreatic cancer cell proliferation via down-regulating AKT activation.Toxicology and Applied Pharmacology. 2014(in press)25.Zhengxi Hu,Jianping Wang, Xiaobin Bi,Jinwen Zhang, Yongbo Xue*, Zengwei Luo, Guangmin Yao, Yonghui Zhang*.Colletotrichumine A, a novel indole-pyrazine alkaloid with an unprecedented C16N3-type skeleton from cultures of Colletotrichum capsici. Tetrahedron Letters. 55 (2014) :(in press)24. Ying TANG, Yong-bo XUE, Lei ZHOU, Jin-wen ZHANG, Guang-min YAO, Zeng-wei LUO, Guang DU*, and Yong-hui ZHANG*。New Norclerodane Diterpenoids from the Tubers of Dioscorea bulbifera L. CHEMICAL & PHARMACEUTICAL BULLETIN.2014(in press)23.Junfen Zeng, Yongbo Xue, Penghua Shu, Huiqin Qian, Rongjian Sa, Ming Xiang, Xiao-Nian Li,Zengwei Luo, Guangmin Yao,*and Yonghui Zhang*.Diterpenoids with Immunosuppressive Activities from Cinnamomum cassia. J. Nat. Prod. 2014, 77, 1948−1954. (IF3.947) 22. Zhengxi Hu, Yongji Lai, Jinwen Zhang, Ye Wu, Zengwei Luo,Guangmin Yao, Yongbo Xue*, Yonghui Zhang*.Phytochemical and chemotaxonomic studies on Phyllanthus urinaria. Biochemical Systematics and Ecology 56 (2014) 60-64(IF1.153)21. Hucheng Zhu,Lijun Huan,Chunmei Chen,Jing Yang,Jiangbo He,Yong Chen,Guangmin Yao,Zengwei Luo,Yongbo Xue*, Yonghui Zhang*. A Pair of Unprecedented Cyclohexylethanoid Enantiomers Containing Unusual Trioxabicyclo[4.2.1]nonane Ring fromClerodendrum bungei.Tetrahedron Letters. 55 (2014) 2277–2279. (IF2.397)20. Fuqian Wang, Shishi Han, Song Hu, Yongbo Xue, Jianping Wang, Hongfeng Xu,Lu Chen, Geng Zhang* , Yonghui Zhang* . Two New Secondary Metabolites from Xylaria sp. cfcc 87468 . Molecules 2014, 19, 1250-1257. (IF2.428)19.Yingda Yang1, Zhengxi Hu, Zengwei Luo, Yongbo Xue, Guangmin Yao, Yanyan Wang*, Yonghui Zhang *. A New Sesquilignan Glucoside from Uraria sinensis. Molecules .2014, 19, 1178-1188. (IF2.428) 18. Heng Zheng,Qiong Chen, Mengke Zhang, Yongji Lai, Liang Lei, Penghua Shu, Jinwen Zhang, Yongbo Xue, Zengwei Luo, Yan Li, Guangmin Yao*, and Yonghui Zhang*.Cytotoxic ent-Kaurane Diterpenoids from Salvia cavaleriei J. Nat. Prod.2013, 76, 2253−2262. (IF3.947)17.Chunmei Chen, Hucheng Zhu, De Zhao, Jun Deng, Yonghui Zhang*.Two new lignans from Phryma leptostachya L. Helvetica Chimica Acta. 2013,96: 1392–139616.Yongji Lai, Yongbo Xue, Mengke Zhang,Jinwen Zhang, Wei Tang, Junjun Liu, Liang Lei, Juming Yan, Zengwei Luo, Jianping Zuo, Yan Li, Guangmin Yao*, Zhang, Yonghui*. Scapiformolactones A-I: germacrane sesquiterpenoids with an unusual 3-15,6-lactone moiety from the whole plants of Salvia scapiformis. Phytochemistry. 96(2013) 378-388. (IF3.05)15.Zhengxi Hu , Yongbo Xue , Guangmin Yao , Zengwei Luo , Yanyan Wang*, Yonghui Zhang*. Chemical constituents from the leaves of Premna microphylla Turcz. J. Chin. Pharm Sci. 2013, 22 (5), 431–43414.Xincai Hao,Jinwen Zhang, Guanqun Zhan,Yongbo Xue,Zengwei Luo, Guangmin Yao,* and Yonghui Zhang*.Chemical constituents from Teucrium viscidum. Biochemical Systematics and Ecology 51 (2013) 78–82(IF1.153)13.Yongji Lai, Shuiping Ding, Huiqin Qian, Jinwen Zhang, Yongbo Xue,Zengwei Luo, Guangmin Yao,* and Yonghui Zhang*. A new lignan glucoside from the whole plants of salvia scapiformis. Molecules .2013, 18, 11377-11383.(IF2.428)12. Penghua Shu, Xialan Wei, Yongbo Xue, Weijie Li, Jinwen Zhang, Ming Xiang, Mengke Zhang,Zengwei Luo, Yan Li, Guangmin Yao,* and Yonghui Zhang*. Wilsonols A−L, Megastigmane Sesquiterpenoids from the Leaves of Cinnamomum wilsonii. J. Nat. Prod. 2013, 76, 1303−1312. (IF3.947) 11. Mengke Zhang, Yan Zhu, Guanqun Zhan, Penghua Shu, Rongjian Sa, Liang Lei,Ming Xiang, Yongbo Xue, Zengwei Luo, Qian Wan, Guangmin Yao*, and Yonghui Zhang*.Micranthanone A, a New Diterpene with an Unprecedented Carbon Skeletonfrom Rhododendron micranthum. Org. Lett.2013,15(12):3094-3097(IF=6.142)10. Wei Xialan, Shu Penghua, Liu Tingting, Xiang Ming, Zhang Jinwen, Xue Yongbo, Luo Zengwei, Yao Guangmin*, Zhang Yonghui*. Steroids and Phenylpropanoids with Immunomodulatory Activities from the Stem Barks of Cinnamomum wilsonii. Chin. J. Org. Chem., 2013, (33):1273-1278.9.Xincai Hao, Jinwen Zhang, Guangxin Xia, Yongbo Xue, Zengwei Luo, Yanyan Si 1,Guangmin Yao*, Yonghui Zhang*.A New Triterpenoid from Teucrium viscidum. Molecules. 2013,18:1262-1269.(IF2.428)8. Zengwei Luo, Bo Yang, Cheng Zhong, Fang Tang, Min Yuan, Yongbo Xue, Guanmin Yao, Jingwen Zhang*, Yonghui Zhang*. A dual-channel probe for selective fluoride determination and application in live cell imaging. Dyes and Pigments. 2013, 97:52-57 (IF3.126) 7.Jieru GUO, Jinwen ZHANG, Guangmin YAO, Mei LIAO, Huadong CHEN, Xixiong YANG*, Yonghui ZHANG*. Hepatoprotective Activity of the Ethanol Extract of Sarcopyramis Nepalensis. Journal of Huazhong University of Science and Technology[Medical Edition], 2012, 32(6):663-666 6.Zengwei Luo, Fuqian Wang, Jinwen Zhang, Xingyao Li, Mengke Zhang, Xincai Hao,Yongbo Xue, Yan Li, F. David Horgen, Guangmin Yao*, Yonghui Zhang*.Cytotoxic Alkaloids from the Whole Plants of Zephyranthes candida. J. Nat. Prod. 2012, 75:2113-2120. (IF3.947)5.Jieru Guo, Jinwen Zhang, Penghua Shu, Lingmei Kong, Xincai Hao, Yongbo Xue, Yan Li, Gao Li, Guangmin Yao*,Yonghui Zhang*.Two New Diterpenoids from the Buds of Wikstroemia chamaedaphne. Molecules.2012,17:6424-6433. (IF2.428)4.Jian-Ping Wang,Ya-Ming Zhou, Yong-Hui Zhang*.Kirenol production in hairy root culture of Siegesbeckea orientalis and its antimicrobial activity. Pharmacognosy Magazine.2012,8(30) :149-155. (IF1.159)3.Chen J, Lei Y, Wu G, Zhang Y*, Fu W, Xiong C, Ruan J*.Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines. J Ethnopharmacol.2012,139(1) :207-213. (IF3.014)2.Yong-Fang Lei, Jing-Lou Chen, Han Wei, Chao-Mei Xiong, Yong-Hui Zhang*, Jin-Lan Ruan*. Hypolipidemic and anti-inflammatory properties of Abacopterin A from Abacopteris penangiana in high-fat diet-induced hyperlipidemia mice. Food and Chemical Toxicology.2011,49 (12):3206-3210. (IF2.999)1. Jin-Wen Zhang, Mei Liao, Hua-Dong Chen, Yong-Hui Zhang*. Structural elucidation of a new flavone from Sarcopyramis nepalensis. Journal of Asian Natural Products Research. 2011,13(3):256–259 (IF0.944) (三)教材编写及组织会议情况8)国家规划本科生统编教材《天然药物化学》(人民卫生出版社),编委,2011年;7)国家规划本科生统编教材《天然药物化学》配套教材《天然药物化学习题集》(人民卫生出版社) 编委,2011年6)高等院校药学与制药工程专业规划教材《天然药物化学》(浙江大学出版社),副主编,2011年5)21世纪高等教育规划教材《有机化合物及药物波谱分析》(华中师范大学出版社),副主编,2008年;4)国家规划本科生统编教材配套教材《天然药物化学习题集》(人民卫生出版社) 编委,2007年;3)《药物计量学》 (中国医药科技出版社),主译之一,2007年;2)国家规划本科生统编教材配套教材《天然药物化学学习指导》(人民卫生出版社) 编委,2005年;1)本科生统编教材《有机化合物波谱解析》(中国医药科技出版社),参编,2004年第一版及2006年第二版。
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1 | 理学 | ------------ | 论文:168篇 | 2 | 化学 | ------------ | 论文:144篇 | 3 | 医学 | ------------ | 论文:41篇 | 4 | 药学 | ------------ | 论文:24篇 | 5 | 基础医学 | ------------ | 论文:12篇 | 6 | 生物学 | ------------ | 论文:11篇 | 7 | 临床医学 | ------------ | 论文:5篇 | 8 | 农学 | ------------ | 论文:1篇 | 9 | 兽医学 | ------------ | 论文:1篇 |
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1 | J NAT PROD | ------------ | 论文:49篇 | 2 | PHYTOCHEMISTRY | ------------ | 论文:46篇 | 3 | BIOORG CHEM | ------------ | 论文:35篇 | 4 | ORG LETT | ------------ | 论文:33篇 | 5 | ORG CHEM FRONT | ------------ | 论文:23篇 | 6 | FITOTERAPIA | ------------ | 论文:22篇 | 7 | J ORG CHEM | ------------ | 论文:14篇 | 8 | NAT PROD RES | ------------ | 论文:14篇 | 9 | SCI REP-UK | ------------ | 论文:12篇 | 10 | MOLECULES | ------------ | 论文:12篇 | 11 | CHINESE CHEM LETT | ------------ | 论文:12篇 | 12 | ORG BIOMOL CHEM | ------------ | 论文:12篇 | 13 | J ASIAN NAT PROD RES | ------------ | 论文:10篇 | 14 | TETRAHEDRON LETT | ------------ | 论文:9篇 | 15 | NAT PRODUCT BIOPROSP | ------------ | 论文:7篇 | 16 | CHINESE J CHEM | ------------ | 论文:7篇 | 17 | CHEM BIODIVERS | ------------ | 论文:7篇 | 18 | RSC ADV | ------------ | 论文:6篇 | 19 | ANGEW CHEM INT EDIT | ------------ | 论文:6篇 | 20 | MAR DRUGS | ------------ | 论文:6篇 | 21 | J AGR FOOD CHEM | ------------ | 论文:6篇 | 22 | CURR MED SCI | ------------ | 论文:4篇 | 23 | BIOCHEM SYST ECOL | ------------ | 论文:4篇 | 24 | FRONT PHARMACOL | ------------ | 论文:4篇 | 25 | CHIN J NAT MEDICINES | ------------ | 论文:4篇 | 26 | J ETHNOPHARMACOL | ------------ | 论文:3篇 | 27 | CHEM RES CHINESE U | ------------ | 论文:3篇 | 28 | TETRAHEDRON | ------------ | 论文:3篇 | 29 | CHEM SCI | ------------ | 论文:3篇 | 30 | J HUAZHONG U SCI-MED | ------------ | 论文:2篇 | 31 | FRONT CHEM | ------------ | 论文:2篇 | 32 | CHEM PHARM BULL | ------------ | 论文:2篇 | 33 | PHARMACOGN MAG | ------------ | 论文:2篇 | 34 | MBIO | ------------ | 论文:2篇 | 35 | BRIT J PHARMACOL | ------------ | 论文:2篇 | 36 | EUR J ORG CHEM | ------------ | 论文:2篇 | 37 | BIOORGAN MED CHEM | ------------ | 论文:2篇 | 38 | MEDCOMM | ------------ | 论文:2篇 | 39 | EUR J PHARMACOL | ------------ | 论文:2篇 | 40 | PHARMACOL RES | ------------ | 论文:1篇 | 41 | EUR J IMMUNOL | ------------ | 论文:1篇 | 42 | ISCIENCE | ------------ | 论文:1篇 | 43 | CARCINOGENESIS | ------------ | 论文:1篇 | 44 | J MED CHEM | ------------ | 论文:1篇 | 45 | CHIN HERB MED | ------------ | 论文:1篇 | 46 | J MOL CELL CARDIOL | ------------ | 论文:1篇 | 47 | J IMMUNOL | ------------ | 论文:1篇 | 48 | ECOTOX ENVIRON SAFE | ------------ | 论文:1篇 | 49 | HEPATOLOGY | ------------ | 论文:1篇 | 50 | REC NAT PROD | ------------ | 论文:1篇 | 51 | J CHEM RES | ------------ | 论文:1篇 | 52 | PHYTOCHEM LETT | ------------ | 论文:1篇 | 53 | FOOD CHEM TOXICOL | ------------ | 论文:1篇 | 54 | OXID MED CELL LONGEV | ------------ | 论文:1篇 | 55 | CHINESE J ORG CHEM | ------------ | 论文:1篇 | 56 | PHYTOMEDICINE | ------------ | 论文:1篇 | 57 | LETT ORG CHEM | ------------ | 论文:1篇 | 58 | SYNTHESIS-STUTTGART | ------------ | 论文:1篇 | 59 | FRONT MICROBIOL | ------------ | 论文:1篇 | 60 | VASC PHARMACOL | ------------ | 论文:1篇 | 61 | QJM-INT J MED | ------------ | 论文:1篇 | 62 | PHARMACEUTICALS-BASE | ------------ | 论文:1篇 | 63 | TOXICOL APPL PHARM | ------------ | 论文:1篇 | 64 | CHEM NAT COMPD+ | ------------ | 论文:1篇 | 65 | REV BRAS FARMACOGN | ------------ | 论文:1篇 | 66 | INT J CLIN EXP MED | ------------ | 论文:1篇 | 67 | Z NATURFORSCH C | ------------ | 论文:1篇 | 68 | BIOMED RES INT | ------------ | 论文:1篇 | 69 | ACTA PHARMACOL SIN | ------------ | 论文:1篇 | 70 | NUCLEIC ACIDS RES | ------------ | 论文:1篇 | 71 | BIOCHEM BIOPH RES CO | ------------ | 论文:1篇 | 72 | BIOMOLECULES | ------------ | 论文:1篇 | 73 | HELV CHIM ACTA | ------------ | 论文:1篇 | 74 | J PHARMACEUT BIOMED | ------------ | 论文:1篇 | 75 | MASS SPECTROM LETT | ------------ | 论文:1篇 | 76 | PHARMACEUTICS | ------------ | 论文:1篇 | 77 | NAT PROD REP | ------------ | 论文:1篇 | 78 | CELL COMMUN SIGNAL | ------------ | 论文:1篇 | 79 | GREEN CHEM | ------------ | 论文:1篇 | 80 | NEW J CHEM | ------------ | 论文:1篇 | 81 | VET RES | ------------ | 论文:1篇 | 82 | EUR J MED CHEM | ------------ | 论文:1篇 | 83 | CHEMISTRYOPEN | ------------ | 论文:1篇 | 84 | CELL DEATH DISCOV | ------------ | 论文:1篇 | 85 | CHEM-BIOL INTERACT | ------------ | 论文:1篇 | 86 | ACTA PHARM SIN B | ------------ | 论文:1篇 | 87 | BRIT J DERMATOL | ------------ | 论文:1篇 | 88 | EUR J DERMATOL | ------------ | 论文:1篇 | 89 | BIOMED PHARMACOTHER | ------------ | 论文:1篇 | 90 | CELL DISCOV | ------------ | 论文:1篇 | 91 | THERANOSTICS | ------------ | 论文:1篇 | 92 | FRONT IMMUNOL | ------------ | 论文:1篇 | 93 | AM J TRANSL RES | ------------ | 论文:1篇 | 94 | DYES PIGMENTS | ------------ | 论文:1篇 | 95 | CHEM COMMUN | ------------ | 论文:1篇 | 96 | ADV SCI | ------------ | 论文:1篇 | 97 | FEBS LETT | ------------ | 论文:1篇 | 98 | CELL DEATH DIFFER | ------------ | 论文:1篇 | 99 | CEREB CORTEX | ------------ | 论文:1篇 |
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1 | Cell Discovery(生物学) | ------------ | 论文:1篇 | 2 | Acta Pharmaceutica Sinica B(化学) | ------------ | 论文:1篇 | 3 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION(化学) | ------------ | 论文:6篇 | 4 | CELL DEATH AND DIFFERENTIATION(生物学) | ------------ | 论文:1篇 | 5 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY(农林科学) | ------------ | 论文:6篇 | 6 | NATURAL PRODUCT REPORTS(化学) | ------------ | 论文:1篇 |
1. "全国药学专家学术影响力百强排名(2021年7月)"中排名第97位。
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