Affiliation:
1. Department of Bioengineering, Rice University, Houston, TX 77030, USA.
Abstract
Craniofacial reconstruction requires robust bone of specified geometry for the repair to be both functional and aesthetic. While native bone from elsewhere in the body can be harvested, shaped, and implanted within a defect, using either an in vitro or in vivo bioreactors eliminates donor site morbidity while increasing the customizability of the generated tissue. In vitro bioreactors utilize cells harvested from the patient, a scaffold, and a device to increase mass transfer of nutrients, oxygen, and waste, allowing for generation of larger viable tissues. In vivo bioreactors utilize the patient’s own body as a source of cells and of nutrient transfer and involve the implantation of a scaffold with or without growth factors adjacent to vasculature, followed by the eventual transfer of vascularized, mineralized tissue to the defect site. Several different models of in vitro bioreactors exist, and several different implantation sites have been successfully utilized for in vivo tissue generation and defect repair in humans. In this review, we discuss the specifics of each bioreactor strategy, as well as the advantages and disadvantages of each and the future directions for the engineering of bony tissues for craniofacial defect repair.
Publisher
American Association for the Advancement of Science (AAAS)
Reference103 articles.
1. Oromandibular reconstruction: The history, operative options and strategies, and our experience;Lin P-Y;ISRN Surg,2011
2. Zygomatic arch reconstruction with autogenous rib bone graft in a post irradiated patient—A case report;Ladehinde AL;Niger Postgrad Med J,2005
3. Bone grafts in craniofacial surgery;Elsalanty ME;Craniomaxillofacial Trauma Reconstr,2009
4. Virtual surgical planning in craniofacial surgery;Chim H;Semin Plast Surg,2014
5. Biomaterials & scaffolds for tissue engineering
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献