Tendon to Bone Healing: Differences in Biomechanical, Structural, and Compositional Properties Due to a Range of Activity Levels

Author:

Thomopoulos S.1,Williams G. R.1,Soslowsky L. J.1

Affiliation:

1. McKay Orthopaedic Research Laboratory, University of Pennsylvania, Philadelphia, PA 19104-6081

Abstract

Little knowledge exists about the healing process of the tendon to bone insertion, and hence little can be done to improve tissue healing. The goal of this study is to describe the healing of the supraspinatus tendon to its bony insertion under a variety of loading conditions. Tendons were surgically detached and repaired in rats. Rat shoulders were then immobilized, allowed cage activity, or exercised. Shoulders that were immobilized demonstrated superior structural (significantly higher collagen orientation), compositional (expression of extracellular matrix genes similar to the uninjured insertion), and quasilinear viscoelastic properties (A=0.30±0.10 MPa vs. 0.16±0.08 MPa, B=17.4±2.9 vs. 15.1±0.9, and τ2=344±161s vs. 233±40 s) compared to those that were exercised, contrary to expectations. With this knowledge of the healing response, treatment modalities for rotator cuff tears can be developed.

Publisher

ASME International

Subject

Physiology (medical),Biomedical Engineering

Reference34 articles.

1. Kibler, B. W., 1997, “Rehabilitation of the Shoulder,” Orthopaedic Knowledge Update: Shoulder and Elbow, Norris, T. R., ed., American Academy of Orthopaedic Surgeons, pp. 289–298.

2. Gelberman, R. H., Woo, S. L., Lothringer, K., Akeson, W. H., and Amiel, D., 1982, “Effects of Intermittent Passive Mobilization on Healing Canine Flexor Tendons,” J. Hand Surg. [Am], 7, pp. 170–175.

3. Gomez, M., Woo, S. L., Amiel, D., Harwood, F., Kitabayashi, L., and Matyas, J., 1991, “The Effects of Increased Tension on Healing Medial Collateral Ligaments,” Am. J. Sports Med., 19, pp. 347–354.

4. Iannotti, J. P., Naranja, R. J., and Gartsman, G. M., 1994, “Surgical Treatment of the Intact Cuff and Repairable Cuff Defect: Arthroscopic and Open Techniques,” Orthopaedic Knowledge Update: Shoulder and Elbow, Norris, T. R., ed., Rosemont IL, American Academy of Orthopaedic Surgeons, pp. 151–156.

5. Naranja, R. J., Iannotti, J. P., and Gartsman, G. M., 1994, “Complications in Rotator Cuff Surgery,” Orthopaedic Knowledge Update: Shoulder and Elbow, Norris, T. R., ed., Rosemont IL, American Academy of Orthopaedic Surgeons, pp. 157–166.

Cited by 358 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3