Measurement of Strain in Physical Models of Brain Injury: A Method Based on HARP Analysis of Tagged Magnetic Resonance Images (MRI)
Author:
Bayly, P. V.123, Ji, S.123, Song, S. K.123, Okamoto, R. J.123, Massouros, P.123, Genin G. M.123
Affiliation:
1. Mechanical and Aerospace Engineering 2. Chemistry 3. Biomedical Engineering
Abstract
Two-dimensional (2-D) strain fields were estimated non-invasively in two simple experimental models of closed-head brain injury. In the first experimental model, shear deformation of a gel was induced by angular acceleration of its spherical container. In the second model the brain of a euthanized rat pup was deformed by indentation of its skull. Tagged magnetic resonance images (MRI) were obtained by gated image acquisition during repeated motion. Harmonic phase (HARP) images corresponding to the spectral peaks of the original tagged MRI were obtained, following procedures proposed by Osman, McVeigh and Prince [1]. Two methods of HARP strain analysis were applied, one based on the displacement of tag line intersections, and the other based on the gradient of harmonic phase. Strain analysis procedures were also validated on simulated images of deformed grids. Results show that it is possible to visualize deformation and to quantify strain efficiently in animal models of closed head injury.
Publisher
ASME International
Subject
Physiology (medical),Biomedical Engineering
Reference24 articles.
1. Osman, N. F., McVeigh, E. R., and Prince, J. L., 2000, “Imaging heart motion using harmonic phase MRI,” IEEE Trans Med, 19(3), 186–202. 2. Sosin, D. M., Sniezek, J. E., and Thurman, D. J., 1996, “Incidence of mild and moderate brain injury in the United States, 1991,” Brain Inj, 10, 47–54. 3. Margulies, S. S., Thibault, L. E., and Gennarelli, T. A., 1990, “Physical model simulations of brain injury in the primate,” J. Biomech., 23, 832–836. 4. Gennarelli, T. A., Thibault, L. E., Aams, J. H. et al., 1982, “Diffuse axonal injury and traumatic coma in the primate,” Ann. Neurol., 12, 564–574. 5. Meaney, D. F., Smith, D. H., Ross, D. T., and Gennarelli, T. A., 1995, “Biomechanical analysis of experimental diffuse axonal injury in the miniature pig,” J. Neurotrauma, 12(4), 689–695.
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