Kinetics Study of Endogenous Heat Shock Protein 70 Expression-Reference-Cited by-同舟云学术

Kinetics Study of Endogenous Heat Shock Protein 70 Expression

Published:2003-12-01 Issue:6 Volume:125 Page:794-797
ISSN:0148-0731
Container-title:Journal of Biomechanical Engineering
language:en
Short-container-title:

Author:

Wang Sihong¹,Diller Kenneth R.¹,Aggarwal Shanti J.¹

Affiliation:

1. Department of Biomedical Engineering, ENS612, 1 University Station C0800, The University of Texas at Austin, Austin, TX 78712-0238 Phone: (512) 471-7167 Fax: (512) 471-0616

Abstract

The purpose of this study was to determine the kinetics of HSP70 expression in response to mild thermal stress. The rationale is to produce a basis for design of optimal heating methods to induce HSP70 expression for preconditioning in cardiac surgery. Bovine aortic endothelial cells were heated at 42°C for 0.5 to 5 hours followed by 37°C recovery for 1 to 48 hours. Quantitative analysis of western blot results showed HSP70 expression kinetics is a coupled function of heating temperature and time and of post-heating duration. Bimodal HSP70 expression kinetics were identified which may be an important cause of the “second window of protection” observed by other researchers.

Publisher

ASME International

Subject

Physiology (medical),Biomedical Engineering

Link

http://asmedigitalcollection.asme.org/biomechanical/article-pdf/125/6/794/5537281/794_1.pdf

Reference18 articles.

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