Guselkumab, a Novel Monoclonal Antibody Inhibitor of the p19 Subunit of IL-23, for Psoriatic Arthritis and Plaque Psoriasis: A Review of Its Mechanism, Use, and Clinical Effectiveness

Author:

Kerut Christian K,Wagner Maxwell J,Daniel Charles P,Fisher Claire,Henderson Emmilee J,Burroughs Caroline R,Amarasinghe Sam,Willett Olga,Ahmadzadeh Shahab,Varrassi Giustino,Shekoohi Sahar,Kaye Alan D

Publisher

Springer Science and Business Media LLC

Subject

Aerospace Engineering

Reference46 articles.

1. Development of therapeutic antibodies for the treatment of diseases;Lu RM;J Biomed Sci,2020

2. First-in-human study to assess guselkumab (anti-IL-23 mAb) pharmacokinetics/safety in healthy subjects and patients with moderate-to-severe psoriasis;Zhuang Y;Eur J Clin Pharmacol,2016

3. Guselkumab for the treatment of psoriasis;Machado Á;BioDrugs,2018

4. TREMFYA® (guselkumab) Approved by U.S. Food and Drug Administration as the First Selective Interleukin (IL)-23 Inhibitor for Active Psoriatic Arthritis. (2023). Accessed. March 19, 2023: https://www.jnj.com/tremfya-guselkumab-approved-by-u-s-food-and-drug-administration-as-the-first-selective-interleuki....

5. Clinically uninvolved but not healthy-The skin of patients with atopic dermatitis is primed for itch and inflammation;Moon S;J Eur Acad Dermatol Venereol,2023

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