Perilla frutescens (L.) Britt extract alleviating acute liver injury in mice induced by thioacetamide

Author:

Dang Minh Thanh,Duong Thi Ngoc Le,To Quoc Hoa,Le Van Trinh,Huynh Ngoc Trinh,Truong Hai Nhung

Abstract

Liver fibrosis is a significant public health concern and is one of the leading causes of death worldwide (2019). Perilla (Perilla frutescens (L.) Britt - PF) is a herb with potent anti-inflammatory and antioxidant properties extensively employed in traditional medicine. This study evaluated the hepatoprotective effects of perilla extract on mice with liver damage caused by Thioacetamide (TAA). Mice were induced liver damage by TAA and given perilla extract, then liver damage assessed through indicators: liver function (albumin index), liver enzymes (ALT, AST indices), liver necrosis and fibrosis by histological staining (H&E and Sirius red staining) and expression levels of genes related to fibrogenesis, antioxidant system and inflammation. Acute liver injury mice treated with PF extract decreased WBC count, biochemical indices: AST, ALT; improved serum ALB level; reduced percentage of necrotic and fibrotic area; diminished expression of myofibroblast marker α-sma and inflammatory cytokine IL6; upregulated expression of gene related to antioxidant system GPx, bax. The result suggested that TAA 150 mg/kg caused hepatotoxicity and 100 mg/kg Perilla Frutescens (L.) has a hepaprotective effect that can attenuate liver damage.

Publisher

World Researchers Associations

Subject

Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3