Micromotors based on mesoporous silica tubes for thrombus therapy

Abstract

To solve the problems of traditional drug carriers such as their single structure and lack of graded release, this work designs and synthesizes a kind of microporous–mesoporous silica tube (MST) with a macroporous and mesoporous structure. Then, manganese dioxide (MnO2) nanoparticles prepared using the hydrothermal method are embedded in the macropores to form an MST/Mn micromotor, which is then loaded with heparin and urokinase for thrombolytic therapy. The motion behavior of the micromotor is also investigated. Both static and dynamic thrombolytic therapy are detected, and the results indicate that a better thrombolytic effect can be observed on the MST/manganese micromotor with a motion ability compared with the samples without a motion ability. This research is expected to provide ideas for the design of more effective thrombus treatment agents.