Population Pharmacokinetic−Pharmacodynamic Modeling of Carvedilol to Evaluate the Effect of Cytochrome P450 2D6 Genotype on the Heart Rate Reduction

Author:

Hwang Sejung12ORCID,Lee Soyoung12ORCID,Yoon Jangsoo1ORCID,Chung Jae-Yong134ORCID

Affiliation:

1. Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine, Seoul, Korea.

2. Kidney Research Institute, Seoul National University Medical Research Center, Seoul, Korea.

3. Integrated Major in Innovative Medical Science, Seoul National University Graduate School, Seoul, Korea.

4. Department of Clinical Pharmacology and Therapeutics, Seoul National University Bundang Hospital, Seongnam, Korea.

Funder

Ministry of Food and Drug Safety

Publisher

XMLink

Subject

General Medicine

Reference26 articles.

1. The pharmacology of carvedilol

2. U.S. Food and Drug Administration. Coreg (carvedilol) [package insert]. Updated 2017. Accessed May 7, 2021. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020297s038lbl.pdf

3. Carvedilol in hypertension treatment

4. Clinical Pharmacokinetics and Pharmacodynamics of Carvedilol

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