Chronic atrophic gastritis – An overlooked association with severe vitamin B12 deficiency: A case report and rapid review of literature

Author:

Abosamra Mahmoud12ORCID,Bateman Adrian C13,Jalal Mustafa14ORCID

Affiliation:

1. Department of Gastroenterology, Southampton General Hospital, Southampton, UK

2. Department of Medicine, Hull University Teaching Hospitals, Hull, UK

3. Department of Cellular Pathology, Southampton General Hospital, Southampton, UK

4. Department of Gastroenterology, Royal Bournemouth Hospital, Bournemouth, UK

Abstract

Current guidelines recommend surveillance for gastric adenocarcinoma in patients with extensive chronic atrophic gastritis (CAG), which is considered a premalignant condition. Although the association between vitamin B12 deficiency and CAG is well described, the indication for endoscopic investigation is only advised in patients with pernicious anaemia. Our case did not have evidence of autoimmune or H. pylori infection but despite this she had CAG. We suggest considering gastroscopy for severe, unexplained vitamin B12 deficiency, particularly in this patient group.

Publisher

SAGE Publications

Subject

Education,General Medicine

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