Affiliation:
1. Department for Biomaterials, Faculty for Dentistry, University of Oslo NO-0317 Oslo, Norway
2. Department for Biomaterials, Faculty for Dentistry, University of Oslo NO-0317 Oslo, Norway,
Abstract
The current study compares biocompatibility, cell growth and morphology, pore diameter distribution, and interconnectivity of a novel titanium dioxide (TiO2) bone graft substitute granules with three different commercially available bone graft granules Natix®, Straumann® BoneCeramic, and Bio-Oss®. Human primary mesenchymal stem cells were cultured on the bone graft substitutes and cell viability and proliferation were evaluated after 1 and 3 days. The microstructural properties of the bone graft substitutes were evaluated by scanning electron microscopy, micro-computed tomography analysis, and mechanical testing. The cell viability and proliferation, porosity, interconnectivity, open pore size, and surface area-to-volume ratio of TiO2 granules were significantly higher than commercial bone granules (Bio-Oss® and Straumann ® BoneCeramic).
Subject
Biomedical Engineering,Biomaterials
Cited by
59 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献