Enhancing the Alignment of the Preclinical and Clinical Stroke Recovery Research Pipeline: Consensus-Based Core Recommendations From the Stroke Recovery and Rehabilitation Roundtable Translational Working Group

Author:

Corbett Dale1,Carmichael S. Thomas2,Murphy Timothy H.3,Jones Theresa A.4,Schwab Martin E.56,Jolkkonen Jukka7,Clarkson Andrew N.89,Dancause Numa10,Weiloch Tadeusz11,Johansen-Berg Heidi12,Nilsson Michael13,McCullough Louise D.14,Joy Mary T.2

Affiliation:

1. Department of Cellular and Molecular Medicine, University of Ottawa, Canadian Partnership for Stroke Recovery, Ottawa, Canada

2. Department of Neurology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA

3. Department of Psychiatry, Kinsmen Laboratory of Neurological Research, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada

4. Department of Psychology and Neuroscience Institute, University of Texas at Austin, Austin, TX, USA

5. Institute for Brain Research, University of Zurich, Zurich, Switzerland

6. Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland

7. Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland and Neurocenter, Neurology, University Hospital of Kuopio, Kuopio, Finland

8. Department of Anatomy, Brain Health Research Center, and Brain Research New Zealand, University of Otago, Dunedin, New Zealand

9. Faculty of Pharmacy, The University of Sydney, Sydney, Australia

10. Groupe de Recherche sur le Système Nerveux Central (GRSNC), Département de Neurosciences, Université de Montréal, Montréal, Canada

11. Department of Clinical Sciences, Laboratory for Experimental Brain Research, Lund, Sweden

12. Oxford Centre for Functional MRI of the Brain, John Radcliffe Hospital, Headington, Oxford, UK

13. Hunter Medical Research Institute, University of Newcastle, New Lambton, Australia

14. Department of Neurology, University of Texas Health Sciences Center at Houston, Houston, TX, USA

Abstract

Stroke recovery research involves distinct biological and clinical targets compared to the study of acute stroke. Guidelines are proposed for the pre-clinical modeling of stroke recovery and for the alignment of pre-clinical studies to clinical trials in stroke recovery.

Publisher

SAGE Publications

Subject

General Medicine

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