Affiliation:
1. The First Affiliated Hospital, Sun Yat–Sen University, Guangzhou, Guangdong, China
2. Southern University of Science and Technology, Shenzhen, Guangdong, China
3. Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
4. Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
Abstract
Background. Subcortical infarcts can result in verbal memory impairment, but the potential underlying mechanisms remain unknown. Objective. We investigated the spatiotemporal deterioration patterns of brain structures in patients with subcortical infarction and identified the regions that contributed to verbal memory impairment. Methods. Cognitive assessment and structural magnetic resonance imaging were performed 1, 4, and 12 weeks after stroke onset in 28 left-hemisphere and 22 right-hemisphere stroke patients with subcortical infarction. Whole-brain volumetric analysis combined with a further-refined shape analysis was conducted to analyze longitudinal morphometric changes in brain structures and their relationship to verbal memory performance. Results. Between weeks 1 and 12, significant volume decreases in the ipsilesional basal ganglia, inferior white matter, and thalamus were found in the left-hemisphere stroke group. Among those 3 structures, only the change rate of the thalamus volume was significantly correlated with that in immediate recall. For the right-hemisphere stroke group, only the ipsilesional basal ganglia survived the week 1 to week 12 group comparison, but its change rate was not significantly correlated with the verbal memory change rate. Shape analysis of the thalamus revealed atrophies of the ipsilesional thalamic subregions connected to the prefrontal, temporal, and premotor cortices in the left-hemisphere stroke group and positive correlations between the rates of those atrophies and the change rate in immediate recall. Conclusions. Secondary damage to the thalamus, especially to the left subregions connected to specific cortices, may be associated with early verbal memory impairment following an acute subcortical infarct.
Funder
the Sun Yat-sen University Clinical Research 5010 Program
the Southern China International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases
the Special Funds of Public Interest Research and Capacity Building of Guangdong Province
natural science foundation of guangdong province
the SYSU-CMU Shunde International Joint Research Institute Start-up Grant
the National Key Clinical Department, National Key Discipline
national natural science foundation of china
the National Key R&D Program of China
the Guangdong Provincial Translational Medicine Innovation Platform for Diagnosis and Treatment of Major Neurological Disease
the Guangdong Provincial Engineering Center For Major Neurological Disease Treatment
the Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases
Cited by
11 articles.
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