Symptoms, Physical Activity, and Biomarkers in Children at the End of Leukemia Maintenance Therapy

Author:

Hooke Mary C.12ORCID,Salisbury Derek L.1,Mathiason Michelle A.1ORCID,Kunin-Batson Alicia S.3,Blommer Audrey2,Hutter Jessica2,Mitby Pauline2,Moore Ida4,Whitman Susan4,Taylor Olga5,Scheurer Michael E.5,Hockenberry Marilyn J.5

Affiliation:

1. School of Nursing, University of Minnesota, Minneapolis, MN, USA

2. Cancer and Blood Disorders Program, Children’s Minnesota, Minneapolis, MN, USA

3. School of Medicine, University of Minnesota, Minneapolis, MN, USA

4. College of Nursing, University of Arizona, Tucson, AZ, USA

5. Baylor College of Medicine, Texas Children's Cancer and Hematology Centers, Houston, TX, USA

Abstract

Background: Symptoms in children with acute lymphocytic leukemia (ALL) change over the trajectory of treatment but little is known about their symptoms as treatment ends. Physical activity may help decrease symptom distress and is vital for ongoing development. The role of biomarkers in symptom science is emerging. The purpose of the study was to explore relationships between self-report of symptoms and physical activity, actigraphy measures, and cerebrospinal fluid (CSF) biomarkers. Methods: Participants were children who were ages 3 to 18 years at the time of ALL diagnosis and were now in the last 12-week cycle of ALL maintenance. Self-reports of fatigue, sleep disturbance, depressive symptoms, and physical activity were completed by participants and parents of younger children. Participants wore a wrist actigraph continuously for the 7 days before other measurements. F2-isoprostanes and interleukin-8 were evaluated in CSF samples. Results: Among the 15 participants, self-report of symptoms and physical activity indicated levels similar to healthy peers. F2-isoprostane had a strong positive correlation with fatigue levels and with depressive symptoms. Fatigue, sleep disturbance, and depressive symptoms positively correlated with each other. Actigraph measures showed children met the CDC guidelines for 60 min of daily moderate to vigorous activity; sleep time was slightly less than healthy norms. Discussion: During maintenance therapy, most children return to healthy norms in symptom burden and physical activity. F2-isoprostane in the CSF is a biomarker for fatigue and depressive symptoms. Children who had persistent symptoms experienced them as a cluster, which confirms previous symptom cluster research.

Funder

Arthur Olofson Medical Research Fund at the University of Minnesota Foundation

National Institutes of Health

Publisher

SAGE Publications

Subject

Pediatrics,Oncology (nursing),Advanced and Specialized Nursing,General Medicine

Reference71 articles.

1. Actigraph. (2021a). ActiGraph wGT3X+ activity monitor. https://actigraphcorp.com/actigraph-wgt3x-bt

2. Actigraph. (2021b). Actilife software. https://actigraphcorp.com/support/software/actilife/

3. Effects of Varying Epoch Lengths, Wear Time Algorithms, and Activity Cut-Points on Estimates of Child Sedentary Behavior and Physical Activity from Accelerometer Data

4. Cerebrospinal Fluid Metabolomic Profiles Associated With Fatigue During Treatment for Pediatric Acute Lymphoblastic Leukemia

5. Centers for Disease Control and Prevention. (2022). How much physical activity do children need? https://www.cdc.gov/physicalactivity/basics/children/index.htm

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3