Sensitivity of Salivary Glands to Radiation: from Animal Models to Therapies-Reference-Cited by-同舟云学术

Sensitivity of Salivary Glands to Radiation: from Animal Models to Therapies

Published:2009-09-25 Issue:10 Volume:88 Page:894-903
ISSN:0022-0345
Container-title:Journal of Dental Research
language:en
Short-container-title:J Dent Res

Author:

Grundmann O.¹²,Mitchell G.C.¹²,Limesand K.H.¹²

Affiliation:

1. Department of Nutritional Sciences and

2. Cancer Biology Program, University of Arizona, 1177 E 4th St., Shantz 421, PO Box 210038, Tucson, AZ 85721, USA

Abstract

Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.

Publisher

SAGE Publications

Subject

General Dentistry

Link

http://journals.sagepub.com/doi/pdf/10.1177/0022034509343143

Reference101 articles.

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4. Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction

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