Migraine and aura triggered by normobaric hypoxia

Author:

Frank Florian1ORCID,Faulhaber Martin2,Messlinger Karl3ORCID,Accinelli Chiara1,Peball Marina1,Schiefecker Alois1,Kaltseis Katharina1,Burtscher Martin2,Broessner Gregor1

Affiliation:

1. Department of Neurology, Headache Outpatient Clinic, Medical University of Innsbruck, Innsbruck, Austria

2. Department of Sport Science, Leopold-Franzens University of Innsbruck, Innsbruck, Austria

3. Institute of Physiology and Pathophysiology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

Abstract

Background For future experimental studies or the development of targeted pharmaceutical agents, a deeper insight into the pathophysiology of migraine is of utmost interest. Reliable methods to trigger migraine attacks including aura are desirable to study this complex disease in vivo. Methods To investigate hypoxia as a trigger for migraine and aura, we exposed volunteers diagnosed with migraine, with (n = 16) and without aura (n = 14), to hypoxia utilizing a hypoxic chamber adjusted to a FiO2 of 12.6%. The occurrence of headache, migraine, aura, and accompanying symptoms were registered and vital signs were collected for 6 hours under hypoxia and 2 hours of follow-up. A binary logistic regression analysis examined the probability of triggering headaches, migraines, aura, photo- and phonophobia. Findings Of 30 participants, 24 (80.0%) developed headaches and 19 (63.3%) migraine, five (16.7%) reported aura. Two patients that developed aura never experienced aura symptoms before in their life. The increase of mean heart frequency was higher in patients developing headaches or migraine. Mean SpO2 during hypoxia was 83.39%. Conclusion Hypoxia was able to trigger migraine attacks and aura independently of any pharmacological agent.

Publisher

SAGE Publications

Subject

Neurology (clinical),General Medicine

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