Functional magnetic resonance imaging in migraine: A systematic review

Author:

Schramm Severin1,Börner Corinna23,Reichert Miriam1,Baum Thomas1,Zimmer Claus14,Heinen Florian2,Bonfert Michaela V23ORCID,Sollmann Nico145ORCID

Affiliation:

1. Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

2. LMU Hospital, Dr. von Hauner Children’s Hospital, Department of Pediatric Neurology and Developmental Medicine, Munich, Germany

3. LMU Center for Children with Medical Complexity, iSPZ Hauner, Ludwig Maximilian University, Munich, Germany

4. TUM-Neuroimaging Center, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

5. Department of Diagnostic and Interventional Radiology, University Hospital Ulm, Ulm, Germany

Abstract

Background Migraine is a highly prevalent primary headache disorder. Despite a high burden of disease, key disease mechanisms are not entirely understood. Functional magnetic resonance imaging is an imaging method using the blood-oxygen-level-dependent signal, which has been increasingly used in migraine research over recent years. This systematic review summarizes recent findings employing functional magnetic resonance imaging for the investigation of migraine. Methods We conducted a systematic search and selection of functional magnetic resonance imaging applications in migraine from April 2014 to December 2021 (PubMed and references of identified articles according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines). Methodological details and main findings were extracted and synthesized. Results Out of 224 articles identified, 114 were included after selection. Repeatedly emerging structures of interest included the insula, brainstem, limbic system, hypothalamus, thalamus, and functional networks. Assessment of functional brain changes in response to treatment is emerging, and machine learning has been used to investigate potential functional magnetic resonance imaging-based markers of migraine. Conclusions A wide variety of functional magnetic resonance imaging-based metrics were found altered across the brain for heterogeneous migraine cohorts, partially correlating with clinical parameters and supporting the concept to conceive migraine as a brain state. However, a majority of findings from previous studies have not been replicated, and studies varied considerably regarding image acquisition and analyses techniques. Thus, while functional magnetic resonance imaging appears to have the potential to advance our understanding of migraine pathophysiology, replication of findings in large representative datasets and precise, standardized reporting of clinical data would likely benefit the field and further increase the value of observations.

Publisher

SAGE Publications

Subject

Neurology (clinical),General Medicine

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