Predictive Value of Complete Blood Count-Derived Inflammatory Markers for 5-Year Survival After Carotid Endarterectomy: Implications for Practice

Author:

Casanova Núria12ORCID,Diaz-Duran Carles1ORCID,Nieto Lluís1,Llort Carme1,Elosua Roberto345,Clara Albert124

Affiliation:

1. Vascular Surgery Department, Hospital del Mar, Barcelona, Spain

2. Universitat Autònoma de Barcelona/Universitat Pompeu Fabra, Barcelona, Spain

3. Cardiovascular Epidemiology and Genetics, IMIM (Hospital del Mar Research Institute), Barcelona, Spain

4. CIBER Cardiovascular, Barcelona, Spain

5. Universitat de Vic – Universitat Central de Catalunya, Barcelona, Spain

Abstract

Complete blood count inflammatory markers (CBC-IMs) have been associated with cardiovascular diseases and mortality. We aimed to evaluate the relationship between preoperative CBC-IMs and 5-year survival after carotid endarterectomy (CEA). Retrospective analysis of 411 consecutive patients who underwent CEA between 2004 and 2018 was done. CBC-IM included the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte (LMR) ratio, and systemic immune-inflammation index (SII). Survival rate at 5 years was 79.8%. Age (hazard ratio (HR) = 1.05, P = .003), hemoglobin (HR = 0.78, P < .001), heart failure (HR = 2.91, P = .005), American Society of Anesthesiologists (ASA)-IV score (HR = 2.41, P = .043), and active neoplastic disease (HR = 2.61, P = .028) were independently related to survival. The discrimination of this model (C-statistic) was 0.698. Spline analysis showed a linear relationship between survival and NLR ( P < .001), PLR ( P < .001), and SII ( P < .001). After adjusting for the baseline predictive score, there was a significant relationship between survival and NLR (HR = 1.191, P = .001), PLR (HR = 1.004, P = .017), and SII (HR = 1.001, P < .001). The addition of NLR, PLR, and SII to the survival model improved the continuous net reclassification index (c-NRI) by 0.29 ( P = .028), 0.347 ( P = .008), and 0.481 ( P < .001), respectively, but not the C-statistic. CBC-IMs show a linear and independent relationship with 5-year survival after CEA and may moderately contribute to patient selection for this preventive intervention.

Publisher

SAGE Publications

Subject

Cardiology and Cardiovascular Medicine

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