Affiliation:
1. Department of Endocrinology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
2. Department of Endocrinology, the Affiliated Wenling Hospital, Wenzhou Medical University; Wenling, Zhejiang, China
3. Department of Emergency, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
Abstract
Autoimmune polyglandular syndrome (APS) is a rare disease that is characterized by autoimmune reactions to multiple endocrine and non-endocrine organs, which can be divided into four main types. The principal manifestations of APS-3 are autoimmune thyroid disease and other autoimmune diseases, such as type 1 diabetes, atrophic gastritis, pernicious anemia, vitiligo, alopecia, and myasthenia gravis, but not Addison’s disease or hypoparathyroidism. Here we report a case demonstrating the rare coexistence of growth hormone deficiency and hyperthyroidism with sexual dysgenesis, secondary amenorrhea, cardiomegaly, splenomegaly, hypoproteinemia, pleural effusion, seroperitoneum, pericardial effusion, anasarca, osteoporosis, vitamin D deficiency, iron-deficiency anemia, poor blood coagulation, leucocytopenia, peripheral neuropathy, hyperuricemia, ichthyosis, tinea cruris, and onychomycosis.
Funder
Zhejiang medical science and technology projects
Public Welfare Technology Application Research Project of Zhejiang Province
Subject
Biochemistry, medical,Cell Biology,Biochemistry,General Medicine
Cited by
1 articles.
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