Clinical features and biological markers of lung cancer-associated stroke

Author:

Xie Xingrui1,Chen Li1,Zeng Jinsheng2,Qin Chao1,Cheng Daobin1,Wei Xinxian1,Liang Zhijian1

Affiliation:

1. Department of Neurology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China

2. Department of Neurology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

Abstract

Objective To identify the unique clinical features and biological markers of lung cancer-associated stroke. Methods We recruited 102 patients with lung cancer plus stroke, 102 with lung cancer, and 102 with stroke. Detailed information was analysed and compared among groups. Results The groups were age-matched. Patients with lung cancer plus stroke showed multiple lesions involving multiple cerebral artery territories on magnetic resonance imaging, compared with stroke-alone patients. These patients also had a poorer modified Rankin Scale score at 30 days, and high mortality (18.6%). Patients with lung cancer plus stroke had a higher incidence of metastasis, and higher blood levels of D-dimer, CA125 and CA199 compared with patients with lung cancer alone. Multivariate logistic regression analysis showed that levels of D-dimer, CA125 and CA199 were independently related to lung cancer-associated stroke. Conclusion Elevated plasma D-dimer, CA125 and CA199 may be independent risk factors for and biomarkers of lung cancer-associated stroke.

Publisher

SAGE Publications

Subject

Biochemistry (medical),Cell Biology,Biochemistry,General Medicine

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2. Cancer-associated stroke;Український радіологічний та онкологічний журнал;2022-12-29

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4. Clinical impact of cerebral infarction in patients with non-small cell lung cancer;International Journal of Clinical Oncology;2022-02-22

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