Affiliation:
1. Department of Internal Medicine, Division of Intensive Care Medicine, Hacettepe University, Ankara, Turkey
2. Department of Internal Medicine, Hacettepe University, Ankara, Turkey
Abstract
Objectives To evaluate the presence of chronic critical illness (CCI) in COVID-19 patients and compare clinical characteristics and prognosis of patients with and without CCI admitted to intensive care unit (ICU). Methods It was a retrospective, observational study at a university hospital ICU. Patients were accepted as CCI if they had prolonged ICU stay (≥14 days) and got ≥1 score for cardiovascular sequential organ failure assessment (SOFA) score and ≥2 score in other parameters on day 14 of ICU admission which was described as persistent organ dysfunction. Results 131 of 397 (33%) patients met CCI criteria. CCI patients were older ( p = 0.003) and frailer ( p < 0.001). Their Acute Physiology and Chronic Health Evaluation (APACHE) II and SOFA scores were higher, PaO2/FiO2 ratio was lower ( p < 0.001). Requirement of invasive mechanical ventilation (IMV), steroid use, and septic shock on admission were higher in the CCI group ( p < 0.001). CCI patients had higher ICU and hospital mortality than other patients (54.2% vs. 19.9% and 55.7% vs. 22.6%, p < 0.001, respectively). Regression analysis revealed that IMV (OR: 8.40, [5.10–13.83], p < 0.001) and PaO2/FiO2 < 150 on admission (OR: 2.25, [1.36–3.71], p = 0.002) were independent predictors for CCI. Discussion One-third of the COVID-19 patients admitted to the ICU were considered as CCI with significantly higher ICU and hospital mortality.
Subject
Health Policy,General Medicine
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献