Affiliation:
1. Department of Cardiology, Affiliated Hospital of Guilin Medical University, Guilin, China
2. Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Abstract
Heart failure (HF) is a complicated clinical syndrome caused by abnormal cardiac structure and/or function, leading to ventricular filling and/or ejection dysfunction. Pyroptosis is a newly identified form of programmed cell death often accompanied by inflammation during HF. The NLRP3 inflammasome, acting as a caspase-1 activation platform, plays a critical role in the production of key pro-inflammatory cytokines and pyroptosis. Therefore, cell death and inflammasomes are involved in the pathophysiological process of HF. Our paper will review the latest research progress on the relationship among pyroptosis, inflammasomes, and HF.
Funder
National Natural Science Foundation of China
Self-Funded Scientific Research Project of Guangxi Health Department
Key Project of Scientific Research and Technology Development of Qingxiu District of Nanning, Guangxi government
General Program of Natural Science Foundation of Guangxi Province of China
Subject
Immunology,Immunology and Allergy,General Medicine