Use of ceftriaxone as an alternative treatment method in pregnant women diagnosed with syphilis – a single centre experience-Reference-Cited by-同舟云学术

Use of ceftriaxone as an alternative treatment method in pregnant women diagnosed with syphilis – a single centre experience

Published:2023-10-23 Issue:2 Volume:35 Page:130-135
ISSN:0956-4624
Container-title:International Journal of STD & AIDS
language:en
Short-container-title:Int J STD AIDS

Author:

Hartmane Ilona¹²^ORCID,Ivdra Iveta¹²,Mikazans Ingmars¹²,Princevs Aleksejs¹,Teterina Irena³^ORCID,Bondare-Ansberga Vanda¹²^ORCID,Reinberga Lelde¹²

Affiliation:

1. Clinic for Dermatology and Sexually Transmitted Diseases, Riga 1st Hospital, Rīga, Latvia

2. Department of Dermatology and Venereology, Faculty of Medicine, Rīga Stradiņš University, Rīga, Latvia

3. Department of Pharmacology, Rīga Stradiņš University, Rīga, Latvia

Abstract

Background There are few data on the use of ceftriaxone in pregnant women diagnosed with syphilis. The aim of this study was to investigate the safety and efficacy of ceftriaxone as an alternative treatment option for syphilis during pregnancy. Methods A retrospective analysis of 79 pregnant women diagnosed with syphilis and treated with ceftriaxone was conducted. Results No cases of intolerance, Jarisch-Herxheimer reactions, or allergic reactions were recorded. The average time to seronegativation for secondary syphilis with symptoms was 6.14 months ± 2.76, and for latent forms, it was 7.52 months ± 1.84. Patients received no additional treatment. No serious adverse drug reactions were reported. Conclusions Data from our study support the use of ceftriaxone as an effective and safe alternative treatment for pregnant women diagnosed with syphilis when penicillin therapy is contraindicated or unavailable.

Publisher

SAGE Publications

Subject

Infectious Diseases,Pharmacology (medical),Public Health, Environmental and Occupational Health,Dermatology

Link

http://journals.sagepub.com/doi/pdf/10.1177/09564624231206845

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